Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Proteins and genomics

ATLAS of Protein and Genomic Sequences Protein Identification Resource (PIR)... [Pg.393]

The drug target universe expands considerably if we expand our analysis to include biological targets for which medicinal chemists have developed small-molecule leads. Unlike the bioinformatics community which has developed a wealth of public databases to assemble and disseminate protein and genomic sequences, medicinal chemistry structure-activity relationship (SAR) data is... [Pg.811]

Fig. 43.2. Replicative cycle of HIV. (1) The virus gp120 protein binds to CD4 resulting in fusion of the viral envelope and the cellular membrane and the release of viral nucleocapsid into the cytoplasm. (2) The nucleocapsid is uncoated, and viral RNA is reverse transcribed by reverse transcriptase (RT). (3) The resulting double-stranded proviral DMA migrates into the cell nucleus and is integrated into the cellular DMA by integrase (IN). (4) Proviral DNA is transcribed by the cellular RNA polymerase II. (5) The mRNAs are translated by the cellular polysomes. (6) Viral proteins and genomic RNA are transported to the cellular membrane and assemble. Immature virions are released, and polypeptide precursors are processed by the viral protease (PR) to produce mature vital particles. (Adapted from Sierra S, Kupfer B, Kaiser R. Basics of the virology of HIV-1 and its replication. J Clin Virol 2005 34 233 with permission from Elsevier.)... Fig. 43.2. Replicative cycle of HIV. (1) The virus gp120 protein binds to CD4 resulting in fusion of the viral envelope and the cellular membrane and the release of viral nucleocapsid into the cytoplasm. (2) The nucleocapsid is uncoated, and viral RNA is reverse transcribed by reverse transcriptase (RT). (3) The resulting double-stranded proviral DMA migrates into the cell nucleus and is integrated into the cellular DMA by integrase (IN). (4) Proviral DNA is transcribed by the cellular RNA polymerase II. (5) The mRNAs are translated by the cellular polysomes. (6) Viral proteins and genomic RNA are transported to the cellular membrane and assemble. Immature virions are released, and polypeptide precursors are processed by the viral protease (PR) to produce mature vital particles. (Adapted from Sierra S, Kupfer B, Kaiser R. Basics of the virology of HIV-1 and its replication. J Clin Virol 2005 34 233 with permission from Elsevier.)...
Palm A. (2003) Capillary isoelectric focusing developments in protein analysis. In G Marko-Varga and P Oroszlan (eds). Emerging Technologies in Protein and Genomic Material Analysis. Journal of Chromatography Library, Vol. 68, pp. 118-122 209-210. Elsevier Science, New brk. [Pg.178]

Kremser, L. Petsch, M. Blaas, D. Kenndler, E. Labeling of capsid proteins and genomic RNA of human rhinovirus with two different fluorescent dyes for selective detection by capillary electrophoresis. Anal. Chem. 2004, 76,7360-7365. [Pg.16]

The viral proteins and genome are assembled to form the nudeopcapsid stmcture of a mature virion. The viral assembly can occur at different intracellular sites in the C5 toplasm, in the nucleus or on the inner surface of the cell membrane. [Pg.476]

See other pages where Proteins and genomics is mentioned: [Pg.174]    [Pg.5]    [Pg.78]    [Pg.432]    [Pg.441]    [Pg.110]    [Pg.373]    [Pg.43]    [Pg.43]    [Pg.105]    [Pg.106]    [Pg.235]    [Pg.74]    [Pg.202]    [Pg.3]    [Pg.195]    [Pg.97]    [Pg.97]    [Pg.157]    [Pg.402]    [Pg.1540]    [Pg.492]    [Pg.178]   
See also in sourсe #XX -- [ Pg.41 ]



SEARCH



ATLAS of Protein and Genomic Sequences

Functional and Genomic Analysis of the Unfolded Protein Response

Genome-Wide Analyses of mRNA and Proteins

Genomics - assigning function to genes and proteins

Genomics and

© 2024 chempedia.info