From Chlorella vulgaris strain

IMMUNOPOTENTIATING EFFECTS OF A GLYCOPROTEIN FROM CHLORELLA VULGARIS STRAIN CK AND ITS CHARACTERISTICS... 

Antitumor immuno-active glycoprotein from culture supernatant of Chlorella vulgaris strain CK... 

The growth of transplantable Meth A tumor was significantly suppressed in an Ag-specific manner when CVE was administered by not only an i.p. route [30], but orally as well [31]. It has been demonstrated that glycoprotein-rich substance (CVS) from the culture supernatant of Chlorella vulgaris strain CK displayed antitumor effect against experimental metastasis induced by Meth A fibrosarcoma [32]. 

III. Discovery of signal transduction systems via toll-like receptors (TLR) by ARS-2, an active substance showing antitumor activity from a glycoprotein-rich substance (CVS) from culture supernatant of Chlorella vulgaris strain CK... 

In order to determine whether TLRs are involved in the recognition of antitumor glycoprotein, ARS-2, from the culture medium of Chlorella vulgaris strain CAT, we examined IL-12 p40 production by the spleen-adherent cells of mice lacking functional TLR2 or TLR4 in response to ARS-2 in vitro [41]. 

In 1990, researchers at Bristol-Myers Squibb reported the isolation of Bmy-41950 (322) from S. staurosporeus strain R10069 (ATCC 55006). This isolate showed in vitro activity against human colon cancer cells (HCT-116) (307). Two years later, Isono et al. reported the isolation of the same natural product from a different Streptomyces sp., S. platensis subsp. malvinus RK-1409 and named it RK-1409 (7-oxostaurosporine) (322) (308,309). In nature, this isolate was obtained in its optically active form [ Id + 38.3 (c 0.06, CHCI3) (309). The PKC inhibitor RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human erythroleukemia cell line, K-562, induced by phorbol 12,13-dibutyrate (PDBu), and also showed a weak antimicrobial activity against Chlorella vulgaris and Pyricularia oryzae (308). 

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