French compound

French Compound. A substance of unknown composition obtained when dilute nitric acid reacts with a mixture of TNT and lead (or iron). French Compound easily ignites when brought into contact with nitric acid vapor at 100°, Either fragmentation or HE bombs can be loaded with this material and the method of loading is either lump or by compression of powdery. material. This material was used by Russions... 

The above synthesis, although performed on a small scale, is easily scaled up to industrial size (French Pat. 2,669,922, CA 118 P6734U). It is a general procedure for substituting aryl-Br with -OMe or -OEt, giving us the possibility to produce other compounds from already known substances, e.g bromination of MDA yields 6-Br-MDA. This is converted by the above procedure to MMDA-2, 133, active at 25-50mg, 8-12 hrs. 

The demonstration unit was later transported to the CECOS faciHty at Niagara Falls, New York. In tests performed in 1985, approximately 3400 L of a mixed waste containing 2-chlorophenol [95-57-8] nitrobenzene [98-95-3] and 1,1,2-trichloroethane [79-00-5] were processed over 145 operating hours 2-propanol was used as a supplemental fuel the temperature was maintained at 615 to 635°C. Another 95-h test was conducted on a PCB containing transformer waste. Very high destmction efficiencies were achieved for all compounds studied (17). A later bench-scale study, conducted at Smith Kline and French Laboratories in conjunction with Modar (18), showed that simulated chemical and biological wastes, a fermentation broth, and extreme thermophilic bacteria were all completely destroyed within detection limits. 

The behaviours of CD and ORD curves in the vicinity of an absorption band are collectively known as the Cotton effect after the French physicist A. Colton who discovered them in 189S. Their importance in the present context is that molecules with the same absolute conhguration will exhibit the same Cotton effect for the same d-d absorption and, if the configuration of one compound is known, that of closeiy similar ones can be established by comparison. 

Careful metabolic work on this drug by a group of French workers showed that the agent was in fact cleaved to sulfanilamide (83) and the amine, 84, in vivo. Testing of the two fragments revealed that the activity of the drug resided entirely in the sulfanilamide fragment. That compound in fact showed full activity when administered alone in vitro or in vivo. ... 

There seems, however, to-day, to be overwhelming evidence that the French chemists were correct and that citronellol and rhodinol are two very similar, but chemically different, compounds, citronellol being represented by the formula (1) and rhodinol by formula (2). Considerable evidence of this is to be found in the work of Barbier and Locquin. Starting from the acetic esters of ordinary d-citronellol and rhodinol from oil of geranium or rose, they attached hydrogen chloride to the double bond, and obtained the same additive product according to the equations — ... 

This phenol ether has been isolated from French oil of parsley. It is a crystalline compound of the formula Cj3Hjg04, which can be separated by freezing the oil and drying the crystals on porous plates for twenty-four bouts, and recrystallising the product several times from alcohol. Its constitution is as follows —... 

Gold compounds were first used in 1929 by French doctors to treat rheumatoid arthritis. Two of the most commonly used are aurothiomalate (myocrisin) and aurothioglucose (solganol) (Figure 4.52), given by injection of their solutions in doses of up to 25 mg a week for some years. 

In 1896, the French scientist Fienri Becquerel happened to store a sample of uranium oxide in a drawer that contained some photographic plates (Fig. 17.2). He was astonished to find that the uranium compound darkened the plates even though they were covered with an opaque material. Becquerel realized that the uranium compound must give off some kind of radiation. Marie Sklodowska Curie (Fig. 17.3), a young Polish doctoral student, showed that the radiation, which she called radioactivity, was emitted by uranium regardless of the compound in which it was found. She concluded that the source must be the uranium atoms themselves. Together with her husband, Pierre, she went on to show that thorium, radium, and polonium are also radioactive. 

Twenty-five years after its discovery, aluminum was a precious metal. Then a French chemist developed procedures for reducing aluminum compounds using sodium metal. The price of the metal dropped 100-fold. Even so, in 1885 aluminum was a semiprecious metal used for esoteric purposes such as a prince s baby rattle and the cap for the Washington Monument. 

The mechanism of action proposed is based on a direct binding to the channel and the following partial block of the ATP-binding pocket of CFTR (French et al., 1997), a mechanism similar to that used by genistein to inhibit the activity of other ATP-utilizing enzymes such as protein kinases and topoisomerase II (Polkowski and Mazurek, 2000 and refs therein). The selection of flavonoid compounds or the development of synthetic drugs reasonably selective for CFTR activation might be an area for future clinical trials. 

To check if PemB is surface exposed, E. chrysanthemi cells were subjected to proteolysis. Treatment of the cell suspension with trypsin, proteinase K or chimotrypsin at a concentration of 0.1 to 1 mg/ml for 1 h did not cause PemB proteolysis or its liberation into the medium. Cell pre-treatment with EDTA-lysozyme, which renders the periplasmic proteins accessible to proteases, gave no effect. PemB was also resistant to proteolytic digestion in extract of cells disrupted by sonication or in a French press. Only addition of Triton X-100 (up to 0.1%) causing formation of the micelles with PemB lead to a quick proteolyis of this protein (data not shown). In another approach to analyse the PemB exposition, bacterial cells were labelled with sulfo-NHS-biotin. This compound is unable to cross membranes and biotinylation... 

Albertus Magnus. Compound of compounds translated from the French by Lynn Bacarella, 1978. R.A.M.S., 1977. [1], 28p. 

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