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Forward chemical genomics

Forward Chemical Genomics Using a Kinase-biased Compound Library... [Pg.174]

Forward chemical genomics Phenotype or response-driven Traditional drug discovery Molecular target unknown or poorly characterized Phenotypic assays, organ bath, tissue binding assays, etc. Target for Probe ... [Pg.699]

Major strategies in chemical genomics I Forward chemical genomics... [Pg.15]

Identification of protein targets in forward chemical genomics studies... [Pg.29]

Figure 2.3 Diagram representing forward and reverse chemical genomic paradigmsP2]... Figure 2.3 Diagram representing forward and reverse chemical genomic paradigmsP2]...
At each of these general steps, there are many molecular mechanisms that can be involved in drug handling that have a significant bearing on chemical genomics. For example, absorption should not be thought of as a passive process but as a dynamic flux, forwards and backwards, across a set of molecular barriers... [Pg.27]

Neckers L. Development of small molecule Hsp90 inhibitors utilizing both forward and reverse chemical genomics for drug identification. Curr Med Chem 2003 May 10(9) 733-739. [Pg.84]

For timely and informative reviews of chemical genetics, see (a) Lokey, R.S. Forward chemical genetics progress and obstacles on the path to a new pharmacopoeia. Curr. Opin. Chem. Biol. 2003, 7, 91-96, and, (b) Smukste, I., Stockwell, B.R. Advances in Chemical Genetics. Annu. Rev. Genomics Hum. Genet. 2005, 6, 261-286. [Pg.215]

Figure 1.8 The general flowchart of forward chemical genetics/genomics. Figure 1.8 The general flowchart of forward chemical genetics/genomics.
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See also in sourсe #XX -- [ Pg.18 ]



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Case studies in forward chemical genomics

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Model organisms used in forward chemical genomics

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