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Drug handling

Pharmacokinetics The study of physiological and pathophysiological effects on drug handling in the body. [Pg.247]

Some failures will be due to the presence of variants in drug handling. Patients who are rapid acetylators of isoniazid have a slower antituberculous response than slow acetylators (Evans and Clarke, 1961). Asthmatics who do not respond well to (32-agonist bronchodilators may have fewer functioning p2-adrenergic receptors (Drysdale et al., 2000). Variations in the synthesis or structure of the serotonin transporter protein, which is involved in selective reuptake of serotonin by presynaptic neurons, may explain why some patients with depressive disorders respond to selective serotonin reuptake inhibitors and others do not (Steimer et al., 2001). [Pg.167]

III. How Important Are Genetic Variants in Predicting Drug Handling ... [Pg.170]

A. The Polymorphisms Are Not the Mutations That Result in Altered Drug Handling... [Pg.173]

One or more components of a mathematical model that aim to replicate the drug-handling characteristics of a proportion of the body. [Pg.109]

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