Case studies in forward chemical genomics

Reversing the phenotypic changes induced by viral oncogenes 

potential therapeutic agents could suppress the formation of a diseased state conditionally. Since the primary target for depudecin is histone deacetylase, it confirms that this is an excellent druggable target for anticancer erapy (Kwon et al., 1998). 

Identification of small molecules promoting specific differentiation of embryonic stem cells (Sachinidis et al., 2008) 

Cell replacement therapy for severe degenerative diseases such as diabetes, myocardial infarction, or Parkinson s disease through transplantation of somatic cells generated from embryonic stem (ES) cells is a very promising new approach. 

Discovery of new small molecules inhibiting angiogenesis (Kwon, 2006) 

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