Model organisms used in forward chemical genomics

1 Model organisms used in forward chemical genomics 

Monitoring the cellular response to small molecules can be efficiently studied by model organisms. 

Yeast Saccharomyces cerevisiae) (Shawn et al., 2008) cells are easy to grow it contains approximately 6000 genes and shows high genetic 

Large numbers of signaling pathways are very similar between this model organism and mammalian systems, which makes it particularly attractive in chemical genomics screens. 

Yeast is often used in synthetic lethality screens, where wild-type strains or strains having modified genomes via mutation or gene deletion are treated with small molecules, and the resulting phenotypic changes could reveal specific alterations and their functions within the intracellular signaling pathways after comparison of the strains. 

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