Foreign-body response maturation

The humoral and cellular immune systems function jointly as an acquired defence against infection. Whether the humoral or the cellular defence system is predominantly used depends in the individual case on the nature of the pathogen or the foreign body, the reactivity of the organism and the mode of infection. The humoral immune response proceeds via the B-l)miphocytes and plasma cells, while the cellular immune response is mediated via the T-l)miphocytes. The haematopoetic stem cells mature into B-lympho-cytes. These are further transformed to plasma cells, which in turn synthesize IgM, but they can also switch to produce IgA and IgG. (99)... 

The immune system uses self-tolerance to neutralize, destroy, and eliminate any non-self proteins and cells, including microorganisms. Non-self proteins and cells include self-cells (the body s own cells) that have become infected or debilitated (cancer cells). The immune system recognizes self-cells by unique proteins on the surface of self-cells. Foreign cells have different proteins called antigens that stimulate the immune response by the immune system. Immune system cells originate and mature in bone marrow and release into the blood, where immune system cells search for non-self-cells. 

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