Fluothane - Halothane

Trade names Fluothane Halothan Trothane Indications Induction and maintenance of general anesthesia Category Anesthetic, inhalation Half-life N/A... 

Electron Capture Detection and Measurement of Fluothane (Halothane) in Blood... 

Halothane. Halothane or Fluothane, 2-bromo-2-chloro-l,l,l-trifluoroethane [151 -67-7] is a colorless Hquid with a pleasant odor. Its lower flammability limit, 4.8% in 70% N2O/30% O2, renders it essentially nonflammable. It has a vapor pressure of 32.5 kPa (244 mm Hg) at 20 °C and is stable to soda lime. However, it is photochemicaHy reactive. 

Halothane (Fluothane) is a volatile liquid given by inhalation for induction and maintenance of anesthesia Induction and recovery from anesthesia are rapid, and the depth of anesthesia can be rapidly altered. Halothane does not irritate the respiratory tract, and an increase in tracheobronchial secretions usually does not occur. Halothane produces moderate muscle relaxation, but skeletal muscle relaxants may be used in certain types of surgeries. This anesthetic may be given with a mixture of nitrous oxide and oxygen. 

Figure 7.1.7 The molecular structure of halothane (fluothane or 2-bromo-2-chloro-1,1,1- trifluoroethane).

Halothane is a modem and widely used inhalation anesthetic. It begins to act very quickly, which is pleasing to patients, and it is very safe. The only drawback to using it is its hepa-totoxicity. It is used in both short and long-lasting surgical operations. The most common synonym of halothane is fluothane. 

Halothane (Fluothane) 10-30 Yes Some Minimal Decrease Decrease Rare liver dysfunction... 

Halothane (Fluothane) depresses respiratory function, leading to decreased tidal volume and an increased rate of ventilation. Since the increased rate does not adequately compensate for the decrease in tidal volume, minute ventilation will be reduced plasma PaCOz rises, and hypoxic drive is depressed. With surgical anesthesia, spontaneous ventilation is inadequate, and the patient s ventilation must be controlled. 

D) Reflex sympathetic stimulation is a major component of halothane s (Fluothane) cardiovascular profile. 

Desflurane [Suprane] Enflurane [Ethrane] Halothane [Fluothane] Isoflurane [Forane] Methoxyflurane [Penthrane] Sevoflurane [Ultane]... 

Brief History. B.W., a 75-year-old woman, fell at home and experienced a sudden sharp pain in her left hip. She was unable to walk and was taken to a nearby hospital where x-ray examination showed an impacted fracture of the left hip. The patient was alert and oriented at the time of admission. She had a history of arteriosclerotic cardiovascular disease and diabetes mellitus, but her medical condition was stable. The patient was relatively obese, and a considerable amount of osteoarthritis was present in both hips. Two days after admission, a total hip arthroplasty was performed under general anesthesia. Meperidine (Demerol) was given intramuscularly as a preoperative sedative. General anesthesia was induced by intravenous administration of thiopental (Pentothal) and sustained by inhalation of halothane (Fluothane). The surgery was completed successfully, and physical therapy was initiated at the patient s bedside on the subsequent day. 

D Fluothane (Zeneca) F Fluotanc (Zeneca) J Halothane (Hoechst)... 

Halothan ASID (Rusch GB Fluothane (ICI 1957) wfm USA Fluothane (Wycth-Ayersl)... 

Example Inhalation Volatile liquids halothane (Fluothane), Route Inhalation Pregnancy category C Pharmacokinetic Metabolized in liver eliminated via ... 

Halothane (fluothane Figure 13-3) is a volatile liquid at room temperature and must be stored in a sealed container. Because halothane is light-sensitive and subject to spontaneous breakdown, it is marketed in amber bottles with thymol added as a preservative. Mixtures of halothane with oxygen or air are neither flammable nor explosive. 

Halothane (Fluothane) Mechanism unclear. Induces rapid, comfortable anesthesia and skeletal muscle relaxation. i cardiac output, mild T of systemic vascular resistance, typically no effect on heart rate, 1 right atrial pressure, moderate depression of myocardial function, most likely to sensitize myocardium to catecholamines and i baroreceptor reflex. t ventilation control (T tidal volume, >1 rate of breathing, i response to CCfe and hypoxia), bronchodilation (mostpotent), No effect on hypoxic pulmonary vasoconstrictor response, depression of ciliary function and mucous clearance. 

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