Fluoride biochemical effects

S. K. Yang, W. C. Chang, J. D. Huang, Effects of Sodium Fluoride and Cobalt Chloride on the Enantioselectivity of Microsomal and Cytosolic Esterases in Rat Intestinal Mucosa , Biochem. Pharmacol. 1993, 46, 1511 -1514. 

Most researchers have felt that biochemical changes in plant tissues are associated with so many normal growth and stress phenomena that they would have no relevance in field evaluations of air pollution effects. Keller has associated changes in peroxidase activity with different pollution stresses (fluoride and oxidants) in apricot and white ash growing in areas of high pollution, as opposed to those of low pollution. This study suffers from lack of pollution monitoring (although leaves were... 

Heavy metals stimulate or inhibit a wide variety of enzyme systems (16, 71, 72), sometimes for protracted periods (71, 73). These effects may be so sensitive as to precede overt toxicity as in the case of lead-induced inhibition of 8 ALA dehydrase activity with consequential interference of heme and porphyrin synthesis (15, 16). Urinary excretion of 8 ALA is also a sensitive indicator of lead absorption (74). Another erythrocytic enzyme, glucose-6-phosphatase, when present in abnormally low amounts, may increase susceptibility to lead intoxication (75), and for this reason, screens to detect such affected persons in lead-related injuries have been suggested (76). Biochemical bases for trace element toxicity have been described for the heavy metals (16), selenium (77), fluoride (78), and cobalt (79). Heavy metal metabolic injury, in addition to producing primary toxicity, can adversely alter drug detoxification mechanisms (80, 81), with possible secondary consequences for that portion of the population on medication. 

B. Amaez, A. Alfonso, M. Estevez, et al. Effect of purification, theophylline and sodium fluoride on histamine release produced by anti neoplastic drugs on rat mast cells, A distinctive mechanism of action forcarboplatiiL Biochem. Pharmacol 44 533 (1992). 

Katz, J. J. Anhydrous hydrogen fluoride as a solvent for proteins and other biologically important substances. Arch. Biochem. Biophys. 51, 293 (1954) Anhydrous trifluoroacetic acid as a solvent for proteins. Nature 174, 509 (1954) A. L. Koch, W. A. Lamont and J. J. Katz The effect of anhydrous strong acids on ribonuclease and lysozyme. Arch. Biochem. Biophys. 63, 106 (1956). 

Yang, S.F. and G.W. Miller. 1963a. Biochemical studies on the effect of fluoride on higher plants. 1. Metabolism of carbohydrates, organic acids, and amino acids. Biochem. J. 88 505-509. 

Albanus L, Heilberonn E, Sundwall A. Antidote effect of sodium fluoride in organophosphorus anticholinesterase poisoning. Biochem Pharmacol, 1965 14 1375-1381. 

The effects of fluorine in the form of fluoride ions on biochemical processes are dependent upon the dose administered. Owning to the similarity in ionic radii of fluorine (0.129 nm) and hydroxyl (0.133 nm), fluoride ions may replace hydroxyl ions... 

Nabavi, S. M., Habtemariam, S., Nabavi, S. F., Sureda, A., Daglia, M., Moghaddam, A.H., Amani, M.A. (2013). Protective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat s kidney. Mol Cell Biochem., 372(1-2), 233-239. 

Yatani A, Brown AM (1991) Mechanism of fluoride activation of G protein-gated muscarinic atrial K channels. J Biol Chem 266 22872-222877 Yates CM, Simpson J, Russel D, Gordon A (1980) Cholinergic enzymes in neurofibrillary degeneration produced by aluminium. Brain Res 197 269-274 Yokel RA, McNamara PJ (1985) Aluminum bioavailability and disposition in adult and immature rabbits. Toxicol Appl Pharmacol 77 344-352 Zaman K, Mukhtar M, Siddique H, Miszta H (1992) The effect of aluminum on the stromal cells in vitro on bone marrow in rats. Toxicol Ind Health 8 103-109 Zaman K, Zaman W, Dabrowski Z, Miszta H (1993) Inhibition of delta amino-evulinic acid dehydratase activity by aluminum. Comp Biochem Physiol 104C 269-273... 

Moreover, the best analytical procedures available have failed to reveal an increase in the fluorine content of topically treated teeth, although most of the studies of topical applications of fluoride to tooth surfaces have demonstrated caries-preventive effects. The most likely explanation seems to be that fluorine influences the physical and biochemical properties of teeth and particularly of enamel surfaces in vivo perhaps by the surface absorption of minute amounts of fluorine by the OH-apatite of the enamel with the production of a protective layer of acid-resisting fluorapatite. Studies with radioactive fluorine have shown that enamel, dentine, bone, and OH-apatite absorb fluorine according to the Freundlich adsorption isotherm.That physicochemical changes do occur which confer acid-... 

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