FluMist

Influenza Virus Vaccine, Live, Intranasal (FluMist)... 

Attenuated live vaccines are less common than they were a century ago, examples being the original Pasteur rabies vaccine and BCG, but the recent approval of a nasal influenza vaccine, FluMist (Medlmmune Vaccines, Inc., Gaithersburg, MD) shows that the approach remains valid. 

Vaccines Mast cell stabilizers Flumist Nasalcrom... 

In a randomized, double-blind study, trivalent, live, attenuated, cold-adapted intranasal influenza vaccine (FluMist) has been compared with intranasal placebo plus a trivalent injected inactivated influenza vaccine (5). The 200 patients were aged 65 years and over and had chronic cardiovascular or pulmonary conditions or diabetes mellitus. During the 7 days after immunization, sore throat was reported on at least one day by significantly more of the FluMist recipients (15 versus 2%). The increased frequency of sore throat may have been attributable to direct or indirect effects of vaccine virus replication. No other symptom was associated with FluMist. These findings were consistent with evaluations of other live, attenuated, cold-adapted influenza vaccine formulations in older adults. However, further studies of the safety of FluMist are warranted. 

Jackson LA, Holmes SJ, Mendelman PM, Huggins L, Cho I, Rhorer J. Safety of a trivalent live attenuated intranasal influenza vaccine, FluMist, administered in addition to parenteral trivalent inactivated influenza vaccine to seniors with chronic medical conditions. Vaccine 1999 17(15-16) 1905-9. 

Medimmune Vaccines I. Influenza virus vaccine hve, intranasal FluMist 2003-2004 Formula. Package Insert 2003 1—19. 

Influenza Vaccines Fluvin, Flumist, Fluzone, Fluvirin, Fiuarix, Influvac Novartis, GSK, Merck, Sanofi Aventis, Crucell Berna, Tanabe Influenza 1.2 1.9 2.3... 

FluMist (Influenza virus vaccine live, intranasal). Medimmune Vaccines, Inc. US Prescribii information, January 2007. 

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