Fibroblast growth factor family

Burgess WH, Maciag T (1989) The heparin-binding (fibroblast) growth-factor family of proteins. Annu Rev Biochem 58 575-606... 

Acidic and basic fibroblast growth factor family... 

Klagsbrun M. The fibroblast growth factor family structural and biological properties. Prog Growth Factor Res 1989 1(4) 207-235. 

Implicated in induction and differentiation of cartilaginous tissues during development are a number of growth factors and cytokines, including the TGF-P superfamily. Those implicated include bone morphogenetic protein subfamilies, fibroblast growth factor family, insulinlike growth factor family,... 

Yamasaki, M., Miyake, A., Tagashira,S., and Itoh, N., Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family, J. Biol. Chem., 271, 15918, 1996. 

Ozawa, K., Uruno, T., Miyakawa, K., Seo, M., and Imamura, T., Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development, Mol. Brain Res., 41, 279, 1996. 

Three major families of growth factors, namely, bone morphogenetic proteins (BMPs), members of transforming growth factor P-family, the Wnt family, as well as the fibroblast growth factor family, play an important role in cardiogenesis [101]. 

Growth factors Fibroblast growth factor family [194]... 

Delli-Bovi, P., Curatola, A.M., Newman, K.M., Sato, Y. and Moscatelli, D. (1988) Processing secretion and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential. Mol. Cell. Biol. 8 2933-2941. 

Miyamoto, M., Naruo, K.-I., Seko, C., Matsumoto, S., Kondo, T. and Kurokawa, T. (1993) Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family which has a unique secretion property. Mol. Cell. Biol. 13 4251-4259. 

The fibroblast growth factors comprise a gene family of nine members that share substantial sequence homology and have diverse effects in the nervous system 479... 

Wilson DK, Nakano T, Petrash JM, Quiocho FA. 1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family complexed with coenzyme and inhibitor. Biochemistry 1995 34 14323-14330. 

The neurotrophins represent a family of survival and differentiation factors that exert profound effects in the central and peripheral nervous systems. The neurotrophins are currently under investigation as therapeutic agents for the treatment of neurodegenerative disorders and nerve injury either individually or in combination with other trophic factors such as ciliary neurotrophic factor (CNTF) or fibroblast growth factor (FGF). 

The data for specificity are equally surprising. As shown in Table 20.1, an aptamer aimed at basic fibroblast growth factor (bFGF) does not bind tightly to other members of the FGF family or to other proteins known to interact with an acidic substance, heparin (these data were reported in [5]). Similar data exist for aptamers aimed at several reverse transcriptases, serine proteases, P- and L-selectin, and cytokines such as VEGF and PDGF. Aptamers in vitro show extreme specificity for their intended targets. 

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