Ferrets

The shapes, disposition of a magnet relatively to the each other and relatively to the pattern are defined in calculation of magnetic field topography [4]. The geometry like magnets has the fields of identical configuration. It gives the possibility to carry out the calculations as for ferrets so for rare-earth materials. 

Chronic Toxicity. The effects of repeated oral exposure to phthalates for periods ranging from a few days to 2 years have been studied in a number of animal species including rats, mice, hamsters, guinea pigs, ferrets, and dogs (37). 

Although no consistently effective chemical repellent has been developed for vertebrate pests, some promising materials have been tested as repellents that are based on predator avoidance, specifically compounds from the secretions of predators. In 1995, synthetic sulfur compounds (two thietanes, a thiolane, and a substituted methyl sulfide, which were originally identified from the anal glands of the stoat, ferret, and red fox) suppressed browsing by the introduced AustraUan bmsh-tail opossum in New Zealand about as well as FEP (83). Suggestions were made that these compounds can be made more effective by the use of bitter compounds in a cocktail. 

Such trace impurities can actually determine the activity or selectivity of a catalyst. However, this serious problem ia catalyst reproducibiUty can also offer leads toward discovery of new catalytic species, and a promising area of catalyst research iavolves ferreting out which active trace impurities are determining the performance of estabhshed catalysts. 

You should consider obtaining internal and external quality assurance reviews of the study (to ferret out errors in modeling, data, etc.). Independent peer reviews of the QRA results can be helpful by presenting alternate viewpoints, and you should include outside experts (either consultants or personnel from another plant) on the QRA review panel. You should also set up a mechanism wherein disputes between QRA team members (e.g., technical arguments about safety issues) can be voiced and reconciled. All of these factors play an essential role in producing a defendable, high-quality QRA. Once the QRA is complete, you must formally document your response to the project team s final report and any recommendations it contains. 

Anfstieg, m. rise, ascent swelling up boiling up. aofstobem, v.t. ferret out, discover. 

Similarly, widespread control of prairie dogs has been a major factor in the near-extinction of the black-footed ferret. 

The quote is attributed to Rolf Landauer by Mehra ([mehra94], page 540) as part of a remark Landauer made about Feynman s participation at the 1981 MIT Conference. Landauer was referring to Feynman s interest in ferreting out the connections between quantum mechanics and computation, but his sentiment could equally well be extended to encompass Feynman s deep interest in fundamental physics. 

DeFeo, T. T., and Morgan, K. G. (1986). A comparison of two different indicators quin 2 and aequorin in isolated single cells and intact strips of ferret portal vein. Pfluegers Arch. 406 427-429. 

Kihara, Y., and Morgan, J. P. (1989). A comparative study of three methods for intracellular loading of the calcium indicator aequorin in ferret papillary muscles. Biochem. Biophys. Res. Commun. 162 402—407. 

Compound 34 (BCZ-1812, RWJ-270201, peramivir) showed selective inhibition of influenza virus sialidases over bacterial and mammalian sialidases (Babu et al. 2000 Bantia et al. 2001 Sidwell and Smee 2002). Successful inhibition of influenza virus infectivity in vitro (Smee et al. 2001) and upon oral administration in vivo [mice (Bantia et al. 2001) and ferrets, reviewed in Sidwell and Smee 2002] led to human clinical trials of orally administered peramivir (Barroso et al. 2005). While orally administrated peramivir successfully completed animal studies and Phase I and Phase II clinical trials, in which the compound was showing neither major side effects nor toxicity (Sidwell and Smee 2002), preliminary results of the Phase III trials (June 2002) demonstrated no statistically significant difference in the primary efficacy endpoint, possibly due to low bioavailability (Barroso et al. 2005). 

A/Nl His274Tyr Oseltamivir Pathogenicity significantly compromised (ferret) Viral litres reduced c/WT reduced catalytic activity ... 

Aspl98Asn Oseltamivir No apparent fitness impairment (ferret) ... 

Ryan DM, Ticehurst J, Dempsey MH (1995) GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-iV-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets, Antimicrob Agents Chemother 39 2583-2584... 

PROFILE.dat The area-% results for the main compound and 10 impurities are given for nine samples of a bulk chemical use with CORREL to ferret out classes of impurities that presumably are involved in common synthesis pathways. 

Geronimi-Ferret et at (1997) France 37 12/24 Symptoms improved but hospital stay reduced... 

Geronimi-Ferret D, Lesay M, Barges-Bertocchio MH (1997). Medico-economic evaluation of treatment with clozapine versus treatment with previous neuroleptics. Encephale2 h (spec. no. 4), 24—31. 

Experimental animals sueh as miee and ferrets have to be used for the cultivation of some viruses. Growth of the virus is indicated by signs of disease or death of the inoculated animal. 

Subsequent studies have confirmed that the reason for this discrepancy is that the rat is able to rapidly metabolise P-carotene to retinol in the intestine, through the action of intestinal dioxygenase. In contrast humans absorb P-carotene systemically such that plasma levels of P-carotene increase to levels not found in the rodent. A more appropriate animal model is the ferret, which shows a similar metabolism to humans. High levels of plasma P-carotene in the ferret induce the cellular transcription factors c-fos and c-jun, and squamous metaplasia is seen in the lung with or without exposure to cigarette smoke (SCF, 2000). Even after the investment of all these resources it has not been possible for the EU Scientific Committee on Food to set an ADI. 

Carotenoid oxidation products are also supposed to have detrimental effects in vivo. As mentioned earlier, they are suspected to be involved in the adverse effects of high doses of 3-carotene supplementation in smokers and asbestos workers (CARET and ATBC studies) and in smoke-exposed ferrets. The mechanisms potentially involved have been investigated in vitro. P-Apo-8 -carotenal, an eccennic cleavage oxidation product of P-carotene, was shown to be a strong inducer of CYPlAl in rats, whereas P-carotene was not active. Cytochrome P450 (CYP 450) enzymes thus induced could enhance the activation of carcinogens and the destruction of retinoic acid. ... 

Hu, K.Q. et al.. The biochemical characterization of ferret carotene-9,10 -monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo, J. Biol. Chem., 281, 19327, 2006. 

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