Feasibility assessment methodology

3 FEASIBILITY ASSESSMENT METHODOLOGY 22.3.1 Traditional Approach for Feasibility Assessment 

This methodology consists of four core components, namely, process simulation development, equipment rating analysis, heat integration analysis, and opportunity interaction optimization. This methodology has been apphed to numerous process energy retrofit projects (Zhu et al., 2011) with the following common features  

Set revamp Directives Define revamp basis Yield estimates 

Develop simulation 1 to mimic plant operation for the base case 1 Rating analysis for I indentifying equipment t bottlenecks 1 Pinch analysis for 1 indentifying heat 1 integration bottlenecks 1 

Determining modifications Optimizing major DOFs Exploiting interactions 

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In contrast, this chapter will present a feasibility assessment methodology that takes a more proactive view of the feasibility with focus on searching for innovative ways to overcome critical constraints. It is not the intension of this chapter to provide a manual of feasibility assessment, but instead to introduce the methodology and share key lessons. These lessons are gained from experience of conducting numerous feasibility assessment studies. 

HSE, Explosion Hazard Assessment A Study of the Feasibility and Benefits of Extending Current HSE Methodology to Take Account of Blast Sheltering, Health and Safety Executive report HSL/2001/04, Sheffield, 2001. 

From the perspective of clinical trial methodology, concurrent medications can create a dilemma for the investigator by complicating the interpretation of results. Intermediate rescue medications are often required, however, because mood stabilizers are relatively slow in their onset of action. Further, if rescue medications are avoided, this usually introduces the confound of dropouts before the experimental drug can be fully effective. When feasible, a reasonable compromise is the use of modest amounts of a benzodiazepine (BZD), such as lorazepam, only when necessary for a limited time (e.g., 7 to 10 days) into the active phase of treatment. This can reduce the number of nonresponding, highly agitated patients who may otherwise drop out of treatment and in a trial of several weeks, the initial lorazepam effect should have dissipated by the final assessments. 

This study shows that assessment of ERCC 1 mRNA expression in patient tumor tissue is feasible in the clinical setting and predicts response to docetaxel plus cisplatin. Further studies are warranted to optimize methodologies for ERCCI analysis in small tumor samples and to refine a multi-biomarker profile predictive of patient outcome. Other... 

From 1994 to 1999, the L125 project was in the Capability Definition Phase (Phase 1), with DSTO providing predominantly Operations Research (OR) support to define the scope and the feasibility of the project in order to demonstrate that L125 was both needed and viable. As mnch SCS-relevant technology was still considered too immature, the S T effort focused on developing a methodology to assess the effect on dismounted individnal soldier and team performance. This comprised the analytical tools of field assessment, the science of how to do the... 

Adiabatic temperature rise values were obtained in this study as a index of thermal hazard prediction of MEKPO. Feasible reactions at every MEKPO decomposition steps were identified from the possible reaction clusters by obtaining Gibbs free energy of reaction. And for each feasible reaction, enthalpy of reaction, heat capacity values and adiabatic temperature rise were assessed. Thermal inertia and MEKPO mixture composition ratio were considered. Adiabatic temperature rise values for each reaction condition were easily obtained, and by this, it is shown that this approach in this study can be a good methodology to get both qualitative and quantitative risk assessment result for hazardous undesirable reaction. The results were compared with the experimental and simulation data from the reference, and the errors were less than reasonable range. 

An alternative to relative assessmmt is to use a solid whose characteristics are exadly known and for which the interstitial fluid behaviour can be probed in detail. Whilst such an absobae assessment process is (perhaps) experimentally feasible for solids like zeolites, it is draily nd for ill-defined solids such as carbons, which are most in need of assessment We have, dierefore, developed and applied a molecular simulation based methodology for the absolute assessment of adsorption-based characterisation methods. A summary of this mdlmdology with examples of its r lication are given here greater details may be fouml dsenhere [2,3]. 

As one can see from the details presented in the previous section, several assumptions have been made in order to obtain a simple and robust procedure to extract distance information. While these assumptions are intuitively clear and feasible, their verification by reference measurements with another independent method are strongly desirable to assess accuracy of the RE methodology. In the case of Fe(ni)-induced RE, which was the first target of RE studies, a detailed comparison to the distances calculated by molecular modelling has been reported. In the case of Dy(m)-nitroxide pairs, direct experimental measurement of distances in homologous Gd(m)-nitroxide pairs with DEER is possible. Fig. 8 shows the comparison between RE-based and DEER-based distance measurements. One can see that distances from RE measurements are systematically shorter than the distances measured by DEER. 

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