Core component pot

An overall plan view of the FFTF reactor refueling facilities is shown in Fig. 5.2. The principal exreactor component is the closed loop ex-vessel machine (CLEM), shown in Fig. 5.3. The CLEM loads all components into the reactor vessel and removes all components from the reactor core. Fresh driver fuel and all SNF is transferred to and from the reactor in a core component pot (CCP) that can be inserted or removed through one of three fuel transfer ports in the reactor vessel top cover. The in-reactor components consist of three in-vessel handling machines (IVHMs) plus the three in-vessel storage modules. The FFTF requires three IVHMs because of closed test loops in the reactor core which interfere with direct access to the entire reactor core with one machine. 

Ex-vessel transfer machine (EVTM). This rail-mounted transfer cask moves core component pots (CCPs) with fresh fuel and other core components from the EVST to the reactor vessel and moves CCPs with SNF and other core components from the reactor vessel to the EVST. The CCPs are small vessels used to transfer fuel and other components in a temperature-controlled sodium environment. The EVTM is also used for fresh fuel, SNF, and other transfer operations within the reactor service building and remains in the reactor service building during reactor operations. 

Grapple and release core assemblies, core component pots, and port plugs... 

A one pot formation and purification of a 5-arylidine 4-thiazolidinone library has also been reported using polymer scavenging as the principle method of purification. An automated synthesizer was employed to make a parallel array of 4080 4-thiazolidinones, prepared simultaneously from a 3-component condensation of mercaptoacetic acid with an amine and a carbonyl compound. Further structural decoration was then introduced using the libraries from libraries principle where the core template was derivatized via an aldol reaction with a second carbonyl unit at the 5-methylene position (Scheme 2.57) [84]. After both synthetic steps. 

An interesting one-pot, five-component domino process using an intermolecular Diels-Alder reaction of furans with AT-phenylmaleimide as its final step has been used to construct the central core of indolo[2,3- ]carbazoles (Equation 86) <2002AGE4291>. Thus, aminooxazoles produced from an Ugi three-component reaction undergo acylation/intramolecular Diels-Alder/retro-Diels-Alder cycloreversion with pentafluorophenyl arylprop-2-ynoates to give furan derivatives. Subsequent Diels-Alder cycloaddition at elevated temperatures with A -phenylmaleimide produces carbazoles in good yields (Table 5). 

Liu and co-workers have developed an efficient three-component, one-pot, two-step synthesis of 3ff-quinazolin-4-ones from readily available carboxylic acids and amines [ 124] (Scheme 49). The versatility of the methodology is remarkable. Simple variation of the starting materials allows not only for the decoration of the quinazolin-4-one core with diverse substituents, but also... 

Fig. 9.48 Pot core (a) complete unit (b) schematic diagram of structure. (Courtesy of Philips Components Ltd.)...

With all necessary building blocks in hand, one pot syntheses were performed. Pre-activation of donor 47 by p-TolSOTf was followed by addition of acceptor 50 and TTBP. Upon completion of the reaction, addition of acceptor 55, TTBP and promoter p-TolSOTf to the same reaction flask produced sHA tetrasaccharide core 56 in excellent overall yield in just three hours (Table 1, entry 1), which was the only compound that needed purification in this three component one-pot synthesis. 

In a more speculative and intuitive way, 3 and 4 should react in the presence of a base to give intermediates of type 15 (9 compounds), which similarly to entry c should react with 2 to give intermediates 16 (27 compounds) followed by cyclodehydration to yield 17 (27 compounds). Whereas a five component one-pot condensation would maximally yield 243 compounds with one single core structure, the decribed multicomponent cascade approach using reactive building blocks... 

At the same time, the FSTG has been investigating flammability test results based on composite parts of varied materials, sire, thickness and construction. Among the test specimens are honeycomb core sandwich panels and composite laminates. The flammability performance of single components is also being studied. These specimens include different types, densities, and thicknesses of honeycomb core, unpainted panels, and panels coated with a variety of paint and ink colors, as weU as panels that have been bonded, potted and/or edge sealed. 

With these conditions in hand, the development of a one-pot four-component synthesis of pyrrolopyridine was straightforward (Scheme 15.18). Thus, heating a toluene solution (60 °C) of an aldehyde, an amine, and an a-isocyanoacetamide (23) in the presence of ammonium chloride (1.5 equiv) for 4 h afforded the oxazole. After cooling the above reaction mixture to 0°C, an a,fi-unsaturated acyl chloride and triethylamine were introduced to it. Heating to reflux the resulting solution produced then pyrrolo[3,4-b]pyridin-5-one (52). In this one-pot four-component reaction, two C-N bonds and three C-C bonds were created with the formation of a bicyclic core. 

A pyrrole ring is the core structure found in the skeletons of many naturally occurring biomolecules such as globins, porphyrins, vitamins, and so on and constitutes a unit of pharmaceuticals. Most commonly, pyrroles are synthesized by multistep synthetic methods. A one-pot three-component synthesis of 2,3,4,5-tetrasubstituted pyrroles from benzoin, 1,3-dicarbonyls, and ammonium acetate was carried out using SSA under solvent-free conditions (Tamaddon and Farahi, 2012) (Scheme 5.21). Veisi (2010) reported a room temperature synthesis of N-substituted... 

Y. Chi, S. T. Scroggins, J. M. J. Erechet, J. Am. Chem. Soc. 2008, 130, 6322-6323. One-pot multi-component asymmetric cascade reactions catalyzed by soluble star polymers with highly branched non-interpenetrating catalytic cores. 

A consecutive three-component synthesis of pyrazoles [67] starting from (hetero)aroyl chlorides, terminal alkynes, and hydrazines represents an excellent entry to more sophisticated one-pot transformations on the regioselectively substituted heterocyclic core. For instance, the catenation of an electrophilic halogenation step led to a one-pot four-component synthesis of 4-halo pyrazoles 36 (halo = chloro or bromo) in good to excellent yield (Scheme 12.24) [68]. 

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