Bone-fat

Dmg distribution into tissue reservoirs depends on the physicochemical properties of the dmg. Tissue reservoirs include fat, bone, and the principal body organs. Access of dmgs to these reservoirs depends on partition coefficient, charge or degree of ionization at physiological pH, and extent of protein binding. Thus, lipophilic molecules accumulate in fat reservoirs and this accumulation can alter considerably both the duration and the concentration—response curves of dmg action. Some dmgs may accumulate selectively in defined tissues, for example, the tetracycline antibiotics in bone (see Antibiotics,tetracyclines). 

Seabirds liver Seabirds Liver, 11 species 3 species, maximum values Brain, fat, bone, feather... 

Male, 19.5 years old Brain, intestine, fat, bone, skin Liver, pancreas, spleen, lung, stomach, heart, muscle, whole Hair... 

The tensions of inhaled anaesthetics in tissues with a high blood flow—brain, heart, kidney (vessel rich group)—equilibrate quickly with the tensions in blood. The converse is true in tissues having low blood flows, e.g. fat, bone. Muscle occupies an intermediate position. 

Benzene was rapidly distributed throughout the bodies of dogs exposed via inhalation to concentrations of 800 ppm for up to 8 hours per day for 8-22 days (Schrenk et al. 1941). Fat, bone marrow, and urine contained about 20 times the concentration of benzene in blood benzene levels in muscles and organs were 1-3 times that in blood and erythrocytes contained about twice the amount of benzene found in plasma. During inhalation exposure of rats to 1,000 ppm (2 hours per/day, for 12 weeks), benzene was stored longer (and eliminated more slowly) in female and male rats with higher body fat content than in leaner animals (Sato et al. 1975). 

Description Of the Model. Travis et al. (1990) developed a model to describe the pharmacokinetics of benzene in mice, rats, and humans. The model contained five compartments, consisting of liver, fat, bone marrow, and muscle, and organs such as brain, heart, kidney, and viscera, connected by the arterial and venous blood pathways. Michaelis-Menten kinetics was assumed in all species, and occurred primarily in the liver, and to a lesser extent in the bone marrow. The species-specific physiological and chemical parameters were taken from the literature. The metabolic parameters were obtained by fitting the empirical data to the model. 

The rendering industry processes or recycles animal and poultry byproducts such as animal fat, bone, hide, offal, feathers, hoofs, horns, hair, and blood. For example. 

Toluene is readily absorbed from the lung and gastrointestinal tract, although studies in animals suggest absorption occurs more slowly in the gastrointestinal tract. Slow absorption also occurs through skin. Studies of humans and animals indicate that inhaled toluene distributes to tissues that are high in fat content (e.g., body fat, bone marrow, and brain) or well supplied with blood (e.g., liver). It seems reasonable to assume that similar distribution would occur for other routes of exposure. 

Absorption Distribution Metabolism Excretion GI tract, lungs, skin Storage in tissues (plasma proteins, liver and kidney, fat, bone), blood-brain barrier, passage across the placenta, membrane permeability Liver, lungs, kidney, brain, phase I, phase II metabolism Urinary, fecal, exhalation, milk, sweat, sahva... 

Aloe-emodin is 98-99% protein bound (Lang, 1993). Rhein, an active metabolite of aloe-emodin, passes into breast milk, but a laxative effect has not been noted in nursing infants (Lang, 1993 Blumenthal, 1998). Tissue concentrations of aloe-emodin and its metabolites were highest in the rat liver and kidney (Lang, 1993). Concentrations in brown fat, muscle, eyes, perirenal fat, bones, bone marrow, and gonads were low or unmeasurable. 

Perhaps the most characterized stem cell is the one residing in the adult bone marrow - that is, the hematopoietic stem cell which gives rise to aU blood cell types [73]. In addition, mesenchymal stem cells (MSC) are multipotent cells that can be isolated from adult bone marrow and be induced in vitro and in vivo to differentiate into a variety of mesenchymal tissues, including bone, cartilage, tendon, fat, bone marrow stroma, and muscle [74]. 

A similar preparation techniqne has been ntilised by Konstance et al. (1988) on beef chuck. In this case, samples were taken from 2.54 cm thick slices of chnck using a cork borer. The cylinders were then inserted in a previously bored rabber stopper placed on a glass cnp. Components of the chuck meat such as lean, fat, bone and ligament could be separated in terms of AE and colour values. 

There must be adequate bloodflow to target areas of the body otherwise, insufficient dmg particles will reach affected parts of the body. Dmgs can also be stored in fat, bones, muscle, and the eyes. Dmgs that accumulate in fat are called lipid soluble and remain for about three hours because there is low blood flow in fat tissue. 

An embolism occurs when a blood clot or thrombus is formed and released in an inflamed vein, associated with pain and swelling, which is called deep vein thrombosis (DVT). The releaised clot, called an embolus, is carried by the bloodsteam and causes an obstruction in a downstream blood vessel or capillary. An embolus can be either part of a thrombus, or an air bubble, piece of fat, bone marrow, or tumor tissue [3]. 

A T-bone steak is a heterogeneous mixture of white fat, bone, and red meat. Each of these macroscopic items is in turn heterngenecus. For example, the meat is composed of blood vessels, protein structures, fine tendons, etc. 

Bleaching and Treatment op Raw Materials intended for SoAP-MAKiNra Palm Oil—Cotton-seed Oil—Cotton-seed Foots —Vegetable Oils— Animal Fats—Bone Fat—Rosin. 

Fat, bone and lean tissues absorb X-rays and ultrasound to different extents, and therefore either a radiograph or ultrasound image will permit determination of the amounts of different tissues in the body, by measuring the areas (or volumes if scanning... 

In Ayurveda, regulation of diet as therapy has great importance. This is because it considers human body as the product of food. An individual s mental and spiritual development as well as his temperament is influenced by the quality of food consumed by him. Food in human body is transformed first into chyle or Rasa and then successive processes involve its conversion into blood, muscle, fat, bone, bone marrow, and reproductive elements. Thus, food is basic to all the metabolic transformations and life activities. Lack of nutrients in food or improper transformation of food leads to diseases. 

In addition to fat, bone is another tissue that has a relatively low blood flow yet still is the preferential storage location for some chemicals, most notably lead and fluoride. In general, chemicals that are stored in bone are elements (e.g., lead and strontium) that bind to the structure of the bone. As with fatty tissue, chemicals bound to bone can be redistributed if bone tissue is lost, such as in osteoporosis. Lead is not toxic to bone however, both fluoride and strontium are. 

Figure 2. Weights of muscle, fat, bone, and others in carcasses of groups HE andR. Group HE n=5. Group R n=5. Significantly different between groups HE andR fP<0.05) f V=0.06.

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