Failure to respond

The costs of a wrong decision are loss of production, on the one hand, and failure to respond to a real emergency on the other. In order to improve his or her decision basis, the control room worker will usually dispatch others to the source of the emergency signal to declare whether it is spurious (false alarm) or whether it is real, but it is containable without need for depressurizing. This takes up valuable time, during which the situation could escalate dangerously. 

Ovarian enlargement, hemoperitoneum, febrile reactions, multiple pregnancies, hypersensitivity Failure to respond to therapy due to development of antibodies, hypothyroidism, insulin resistance, swelling of the joints, joint and/or muscle pain Same as somatropin... 

Drug treatment failures may result from a variety of factors. Initial failure to respond to a-adrenergic antagonists occurs in 20% to 70% of treated patients. It is likely in these patients that the static factor may predominate as the cause of symptoms in these patients. Initial failure to respond to 5a-reductase inhibitors occurs in 30% to 70% of treated patients. 

Tramadol is a reasonable option for patients with contraindications to NSAIDs or failure to respond to other oral therapies. For the treatment of hip or knee OA, tramadol is as effective as NSAIDs. The addition of tramadol to NSAIDs or acetaminophen may augment the analgesic effects of a failing regimen, thereby securing sufficient pain relief in some patients. Moreover, concomitant tramadol may permit the use of lower NSAID doses. 

Failure to respond to initial therapy after 3 days requires patient reevaluation to consider changing therapy to cover pathogens not treated with the initial choice. Antibiotics traditionally have been given for at least 10 to 14 days, with up to 21 days needed for resolution in some patients.31 Recent data suggest that 5-day treatment courses of some fluoroquinolones and telithromycin are as effective as longer courses in adults with... 

Opioids and derivatives (e.g., meperidine, butorphanol, oxycodone, hydromorphone) provide effective relief of intractable migraine but should be reserved for patients with moderate to severe infrequent headaches in whom conventional therapies are contraindicated or as rescue medication after failure to respond to conventional therapies. Opioid therapy should be closely supervised. 

Failure to respond to pravastatin (B2B2 variant of cholesterol ester transfer protein)... 

More severe disease than is usually expected for a specific pathogen or failure to respond to standard therapy... 

We dehne treatment resistance as the failure to respond fnlly to an adeqnate trial (6 weeks of recognized therapeutic doses) of at least two different antipsychotics. With the recent introduction of several atypical antipsychotics, we fnrthermore snggest that there shonld be failed treatment with at least one typical and one atypical antipsychotic before being considered treatment resistant. 

Because of the small number of patients studied in detail, no valid conclusions could be drawn about the precise limits of plasma chlorpromazine concentration for optimum therapeutic effect. Nevertheless, failure to respond to chlorpromazine was shown in one patient to relate to the extremely low plasma concentrations achieved—even by larger than average daily doses of chlorpromazine—whereas in another patient symptoms were aggravated when plasma levels of chlorpromazine were high. 

Maintenance dosage Most patients require 1 tablet Thyrolar 1 to 1 tablet Thyrolar 2 per day failure to respond to 1 tablet Tf7yro/ar 3 suggests lack of compliance or malabsorption. 

Behaviorai probiems- For the treatment of behavioral problems in children with combative, explosive hyperexcitability that cannot be accounted for by immediate provocation. Reserve for use in these children only after failure to respond to psychotherapy or medications other than antipsychotics. Hyperactivity- For short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of... 

Chagas disease, the South American variety of trypanosomiasis, is caused by Trypanosoma cruzi. It is quite different from African trypanosomiasis in its clinical and pathological presentation and in its failure to respond to many agents effective in that disease. It has both an acute and chronic phase. The latter frequently results in gastrointestinal and myocardial disease that ends in death. 

Failure to respond to an initial medication trial does not predict failure to respond to another drug. If no or little clinical response is noted after 8-10 weeks using maximal therapy or adverse events are unacceptable, a... 

In addition to noncompliance with medication, causes of failure to respond to drug therapy include excessive sodium intake and inadequate diuretic therapy with excessive blood volume, and drugs such as tricyclic antidepressants, nonsteroidal anti-inflammatory... 

Stimulation of the subthalamic nucleus or globus pallidus by an implanted electrode and stimulator has yielded good results for the management of the clinical fluctuations occurring in advanced parkinsonism. The anatomic substrate for such therapy is indicated in Figure 28-1. Such procedures are contraindicated in patients with secondary or atypical parkinsonism, dementia, or failure to respond to dopaminergic medication. 

Failure to respond to a variety of antidepressants, singly or in combination, is the key factor indicating consideration of electroconvulsive therapy (ECT). This is the only therapeutic agent for the treatment of depression that is rapid in onset and can... 

Figure 6 Frequency histogram for time of day of motor vehicle crashes and fall-asleep attacks on the PVT. The open bars represent the 60-min frequency of 4333 crashes in which the driver was judged to be asleep but not intoxicated across the 24-hr day and the solid bars represent fall-asleep attacks (failure to respond for 30 sec on the PVT) in n = 14 subjects, measured at 120-min intervals across 42 hr of total sleep deprivation. Both the fatigue-related crashes and fall-asleep attacks follow an equivalent temporal profile across the day, with occurrences increasing across the nocturnal period, and peaking between 07 00 and 08 00. (Adapted from Refs. 92 and 94.)...

Figure 7 PVT reaction times prior to the first uncontrolled sleep attack during total sleep deprivation. Fourteen subjects completed 42 hr of total sleep deprivation and completed a 20-min PVT every 2 hr (represented by the closed circles) 19 subjects completed 88 hr of total sleep deprivation and completed a 10-min PVT every 2 hr (represented by the open circles). The number of test bouts (up to 30) prior to an uncontrolled sleep attack (failure to respond for 30 sec on the PVT) is represented on the bottom abscissa, with time prior to the sleep attack (up to 6 min) represented on the top abscissa. In both subject groups a progressive decline in performance on the visual PVT was evident within minutes of an uncontrolled sleep attack on console. This study also demonstrated an increase in subjective sleepiness (measured using the Stanford Sleepiness Scale) in the test bouts prior to the one in which the first sleep attack occurred. Taken together, these findings suggest that even a very sleepy subject cannot fall asleep while performing computerized tasks without some levels of awareness. (From Ref. 95.)...

The availability of erythropoietin has had a significant positive impact for patients with chronic renal failure. Erythropoietin consistently improves the hematocrit and hemoglobin level and usually eliminates the need for transfusions in these patients. An increase in reticulocyte count is usually observed in about 10 days and an increase in hematocrit and hemoglobin levels in 2-6 weeks. Most patients can maintain a hematocrit of about 35% with erythropoietin doses of 50-150 IU/kg intravenously or subcutaneously three times a week. Failure to respond to erythropoietin is most commonly due to concurrent iron deficiency, which can be corrected by giving oral iron. Folate supplementation may also be necessary in some patients. 

Once the first office action is received, the applicant is given a limited amount of time to respond. The amount of time given to respond depends on the nature of the office action. For a restriction requirement, an applicant is normally given 1 month. However, the applicant can extend the response time all the way out to 6 months if he is willing to pay a fee that increases for each additional month that the reply is extended. When the office action is on the merits, the response time is normally 3 months, with the possibility of extending the response time out to 6 months, once again by paying an extension fee that increases for each additional month. Failure to respond to an office action in the maximum amount of time will result in the abandonment of the application.39... 

Attrition of Volunteers Due to Death., Loss to Follow-up, and Failure to Respond to Questionnaire, by Chemical Group (Total)a... 

Venlafaxine is often used in high doses in patients with treatment-resistant depression. If there is continuing failure to respond, electroconvulsive therapy might be used, often in combination with venlafaxine. A 73-year-old woman taking venlafaxine (112.5 mg/day) had sustained hypertension for several hours after her first treatment (9). However, electroconvulsive therapy can cause transient hypertension, and the patient had essential... 

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