Insignificant factors

The subject population covariate plays a special role in PK similarity assessment, similar to that of formulation in BE assessment. That is, if the influence of formulation on the rest of the parameters Ka, V, CL, etc.) is not adequately represented in the model, then the model will underrepresent the formulation influence on the predictions of PK parameters and may bias the BE assessment results. To further illustrate this, the conventional model building procedure might find the formulation factor insignificant in the model, and if the final model contains no formulation factor, it will predict the AUC and Cmax ratios to be 1 with certainty, that is, producing confidence intervals of length 0. Thus, BE would have to be declared by default. This is clearly unacceptable from the standpoint of traditional BE assessment, which often finds the formulation term insignificant in ANOVA but always produces confidence intervals of positive lengths for the AUC and Cmax ratios. 

For cakes of high permeabihty, the capillary drain height may be an insignificant fraction of cake thickness, and film drainage becomes the controlling factor in a centrifugal field (7). Under unsteady-state conditions, equation 18 represents the drainable Liquid left in the cake as a function of the centrifugal filtration parameters ... 

Hi = Inlet head, or the losses expressed in feet that occur in the suction throat of the pump up to and including the eye of the impeller. These losses would not be registered on a suction pressure gauge. They could be insignificant, or as high as 2 feet. Some pump manufacturers factor them into their new pumps, and others don t. Also, changes occur in maintenance that may alter the Hi. If you don t know the Hi, call it a safety factor of 2 feet. 

The Hi, inlet head, is simply a. safety factor of 2 feet. Some pumps have an insignificant Hi. Other pumps have inlet losses approaching 2 feet. The Hi is losses to the fluid after it passes the suction pre,s,sure gauge and goes into the impeller eye. In a maintenance function, you can t be precise about what s happening to the fluid in this part of the pump. Just call it 2 feet. 

Using the correlation coefficients, calculate the Student s t factors, and display these (the larger this value, the more probable the correlation values below about 2 are insignificant). 

Vitamin K is a fat-soluble vitamin cofactor for the activation of factors II, VII, IX, and X in the liver. Almost all neonates are vitamin K-deficient at as a result of (1) insignificant transplacental vitamin K crossover, (2) lack of colonization of the colon by vitamin K-producing bacteria, and (3) inadequate dietary vitamin K intake (especially in breast-fed infants because human milk contains less vitamin K than infant formula or cow s milk). Vitamin K-deficiency bleeding (VKDB) refers to bleeding attributable to vitamin K deficiency within first 6 months of life. It occurs in three general time frames early (0-24 hours), classic (1-7 days), and late (2-12 weeks). Early onset occurs rarely and usually is associated with maternal ingestion of anticonvulsants, rifampin, isoniazid, and warfarin. Classic vitamin K-dependent bleeding usually results from the lack of prophylactic vitamin K administration in... 

On the other hand, when K Kf, the concentration of inhibitor required to observe slow binding inhibition would be much less than the value of K, for the inhibitor encounter complex. When, for example, the inhibitor concentration is limited, due to solubility or other factors, and therefore cannot be titrated above the value of Kif the steady state concentration of the El encounter complex will be kinet-ically insignificant. Under these conditions it can be shown (see Copeland, 2000) that Equation (6.6) reduces to... 

All OCPs are polytropic, parenchymatous poisons, afflicting the central nervous system, liver, kidneys, the heart muscle, the stomach and intestines, and the endocrine system (mostly the adrenal glands, thyroid, and ovaries). Morphological changes in warm-blooded creatures poisoned by OCPs vary from insignificant disruptions in circulation and reversible dystrophy to focal necroses these effects depend on the organism, the dose of OCP, how long the OCP remains active, as well as on other factors [9, 39, 40, A47, A79]. 

In the case that interactions prove to be insignificant, it should be gone over to the ab model the estimations of which for the various variance components is more reliable than that of the 2ab model. A similar scheme can be used for three-way ANOVA when the factor c is varied at two levels. In the general, three-way analysis bases on block-designed experiments as shown in Fig. 5.1. 

The activation of H2 photoproduction by CaCl2 was observed not only with Tris buffer as an electron donor but with sucrose, dithiothreitol, or methanol as well. BaCl2, like CaCl2, enhanced the rate of H2 photoproduction by a factor of about 30. Chlorides of monovalent metals increased the reaction rate in the system Tris-Ti02-hydrogenase insignificantly [2],... 

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