F Methyl isocyanate

Butane-1,4-diisocyanate, 2376 f Butyl isocyanate, 1931 4-Chlorophenyl isocyanate, 2648 1,6-Diisocyanatohexane, 3008 Diisocyanatomethane, 1079 2,4-Diisocyanatotoluene, 3117 f Methyl isocyanate, 0761... 

Methylimidazole, 1495 Methyl iminioformate chloride, 0893 Methyl iodide, see Iodomethane, 0444 f Methyl isobutyrate, 1970 f Methyl isocyanate, 0758 Methyl isocyanide, 0756 Methyl isocyanoacetate, 1466... 

At about 12 40 A.M. December 3, 1984, the accident occurred that took 2,500 lives at the Union Carbide (India) Ltd. (UCIL) operated pesticide plant. The first indication of process upset was when the control-room operator (CRO) noted that the temperature in a supposedly refrigerated tank storing methyl isocyanate gas (MIC), had risen to 77° F. The pressure, normally 2 to 25 psi was 55 psi. 

Dodd, D.E., Frank, F.R., Fowler, E.FI., Troup, C.M., and Milton, R.M. Biological effects of short-term, high-concentration exposure to methyl isocyanate. I. Study objectives and inhalation exposure design. Environ. Health Perspect., 72 13-19, 1987. 

Methanol is oxidized to formaldehyde in a thin layer of finely divided silver or a multilayer screen, with a contact time of 0.01 s at 450 to 600°C (842 to 1112°F). A shallow bed of silver catalyst is also used in the DuPont process for in situ production of methyl isocyanate by reacting monomethlyformamide and oxygen at 500°C. 

The Step 1 product (0.176 mmol) and f-butyl isocyanate (0.176 mmol) were dissolved in 1ml CH2C12, then treated with NaH (0.176 mmol), and stirred 24 hours. The mixture was filtered, washed with 1 ml DMF, and concentrated. The residue was purified by chromatography using silica gel with CH2Cl2/methyl alcohol, 25 1, and the product isolated in 36% yield as a white solid. 

Alarie, Y., Ferguson, J.S., Stock, M.F., Weyel, D.A., Schaper, M. (1987). Sensory and pulmonary irritation of methyl isocyanate and pulmonary irritation and possible cyanide-like effects of methyl isocyanate in guinea pigs. Environ. Health Perspect. 72 159-67. 

Ennever, F.K., Rosenkranz, H.S. (1987). Evaluating the potential for genotoxic carcinogenicity of methyl isocyanate. Toxicol. Appl. Pharmacol. 91 502-5. 

Karol, M.H., Taskar, S., Gangal, S., Rubanoff, B.F., Kamat, S.R. (1987). The antibody response to methyl isocyanate experimental and clinical findings. Environ. Health Perspect. 72 169-75. 

Segal, A., Solomon, J.J., Li, F. (1989). Isolation of the methylcarhamoyl-adducts of adenine and cytosine following in vitro reaction of methyl isocyanate with calf thymus DNA. Chem. Biol. Interact. 69 359-72. 

Tepper, J.S., Wiester, M.J., Costa, D.L., Watkinson, W.P., Weber, M.F. (1987). Cardiopulmonary effects in awake rats four and six months after exposure to methyl isocyanate. Environ. Health Perspect. IT. 95-103. 

Uraih, L.C., Talley, F.A., Mitsumori, K., Gupta, B.N., Bucher J.R., Boorman, G.A. (1987). Ultrastructural changes in the nasal mucosa of F344/N rats and B6C3F1 mice following an acute exposure to methyl isocyanate. Environ. Health Perspect. IT. 77-88. 

Mercury compounds Methanol Methoxychlor Methyl bromide Methyl chloride Methyl ethyl ketone Methyl hydrazine Methyl iodide Methyl isobutyl ketone Methyl isocyanate Methyl methacrylate Methyl f-butyl ether... 

Figure 5. Scanning electron micrographs of radially-split southern pine showing swelling of wood treated with methyl isocyanate. Key A, untreated control (245)0 B, 16.0 WPG (224X) C, 32.2 WPG (224X) D, 36.9 WPG (224x) E, 47.4 WPG (224X) F, 72.3 WPG (196X)-...

Thus, heating methyl 2-aminonicotinate under reflux for 16 hours with methyl isocyanate in pyridine gave a 76% yield of 3-methylpyrido[2,3-rf]pyrimidine-2,4(l//,3/f)-dione (R1 = H R2 = Me), whereas the method using ethanolic aqueous potassium hydroxide as catalyst88 could not be repeated.83 The cyclization of 2-(arylamino)nicotinic acid methyl esters with various alkyl isocyanates requires 6 days at reflux in xylene with camphorsulfonic acid as catalyst.91,92... 

ISOCYANATE de METHYLE (French) (624-83-9) see methyl isocyanate. ISOCYANATE METHANE (624-83-9) C2H3NO Highly flammable, polymerizable liquid. Forms explosive mixture with air [explosion limits in air (vol %) 5.3 to 26.0 flash point 0°F/-18°C 19°F/-7°C autoignition temp 995°F/535°C Fire Rating 3]. Decomposes slowly in cold water reacts violently with warm water or steam, forming carbon dioxide, dimethylurea, methylamine. 

METHYL ISOCYANATE (624-83-9) Forms explosive mixture with air (flash point 0°F/— 18 C). Reacts slowly with water, violently with warm water or steam, forming carbon dioxide and heat. Decomposes above 100 F/38°C. Violent reaction with acetaldehyde, amines, alcohols, acids, alkalis, strong oxidizers. Unless inhibited, can produce unstable peroxides contact with iron, tin, copper, or salts of these elements, or with certain catalysts such as triphenylarsenic oxide, triethylphosphine, or tributyltin oxide, or elevated temperatures may cause polymerization. Incompatible with glycols, amides, ammonia, caprolactam. Attacks some plastics, mbber, or coatings. The uninhibited monomer vapor may block vents and confined spaces by forming a solid piolymer material. 

Conner, M. K Rubmson, H. F, Fergusm, J. S Stock, M. F., and Alarie, Y. (1987). Evaluation of sister chromatid exchange and cytotoxicity in murine tissues in vivo and lymphocytes in vitro following methyl isocyanate exposure. Environ. Health Perspect. 72, 177-182. 

Methyl Isocyanate sharp, pungent odor. IDLH 3 ppm MP -49°F BP 139°F... 

---