Isocyanide, methyl

Dehydration of N-methylformamide by />-toluenesulfonyl chloride quinoline to form methyl isocyanide, 46,75... 

Methylene 2 hexanone, 47, 87 5 Methyl 5 hexen 2-one, 47, 87 Methyl hvdrazine, 46, 85 Methyl isocyanide, 46, 7S Methy lmagnesium bromide, reaction with bis(10,9 borazarophenan-thryl) ether, 46, 67 reaction w ith thiophosphoryl chloride, 45,102... 

Methyl isocyanide, 120 Methyl radical, 10 planar, 65 pyramidal, 66 MethyUunine, 103 Methylazkle, 191 Methylene, 6 singlet, 63 triplet, 62... 

Methyl hydrogen sebecate, 41, 34 Kolbe electrolysis of, 41, 33 1-Methylindole,40, 68 Methyl iodide, methylation of dihydroresorcinol with, 41, 57 Methyl isocyanide, 41, 15 Methyl 4-mcthyl-4-nitrovalerate, hydrolysis to acid, 41, 24 N-Methyl-N-nitrosoterephthalamide, preparation of diazomethane from, 41, 16... 

EPR investigations are necessarily carried out in frozen solution at low temperature. Room temperature binding of thiols to FeMoco has been monitored by F NMR spectroscopy using /J-CF3C6H4S as the reporter ligand. These experiments revealed that the binding of thio-late is characterized by a dynamic equilibrium between the FeMoco and thiolate (159) and that cyanide and methyl isocyanide can bind to isolated FeMoco complexed with thiol (160). 

Methyl chloride, phenyl-, 55, 94 Methyl isocyanide, p-tolylsulfonyl-[36635-61-71,58, 104, 106 Methyl sulfoxide [67-68-5], 59, 16 METHYLENECYCLOPROPANE [19527-12-91,57,36... 

In analogy, Ugi et al. reported on a lactam formation by running a one-pot three components reaction the condensation of L-lysine 7, isobutyraldehyde and methyl isocyanide led to the corresponding a-amino-c-caprolactam 9, but the yield was not given. The authors presumed either a nucleophilic substitution of the ester 8 as the primary Ugi product by the amino function of the side chain or, alternatively, the nucleophilic attack of the NH2-group on an intermediately formed 0-acylamide and a subsequent rearrangement (Scheme 1) [4]. 

Reactions of Pt(PPhj)2(R)X (R = CH3, C Hj X = Cl, Br, I) and methyl isocyanide 144) and analogous reactions of Pd(phos)2(CH3)I (phos = PPh3, PPhMc2) complexes with cyclohexyl isocyanide 169, 170) were reported about the same time. As might perhaps be anticipated, the platinum reactions were slower and one can isolate the intermediate species and observe their rearrangement to the inserted products [Eq. (8)]. The isolation of the... 

Subsequent to the initial report by Badley et al. two communications appeared, which reported structural investigations on several products obtained from PtCl4 , methyl isocyanide, and hydrazine 33, 117) these compounds had previously been identified (incorrectly) as six-coordinate platinum(II) species 90). In addition, synthesis work in this area was extended somewhat further by these groups. The details of this work presented in these communications and in later full papers 34, 117) are summarized hy Eqs. (17). 

The reaction of Mn(CO)jBr and methyl isocyanide was also carried out (Table V) the products are analogous to those obtained from phenyl isocyanide and the manganese complex. 

Mixed methyl isocyanide carbonyl manganese(I) cations [Mn(CO)5 j(Ljf]-PFj (L = CNCHj) were prepared by the standard method 154). The... 

It is also appropriate to observe the substantial difference in ease of oxidation between phenyl and methyl isocyanide complexes, which has obvious chemical implication. This may perhaps be rationalized on the basis that phenyl isocyanide is a better 7r-acceptor than methyl isocyanide. This conclusion had previously been reached by infrared studies (see Section II). 

The preparations of a number of rhodium(I) complexes of isocyanides, some of them new, have been described. The newtetrakis(methyl isocyanide) complex, [Rh(CNCH3)4], was isolated as salts of various anions from reactions of RhClj -3H20 or [(l,S-CgH,2)RhCl]2 and this isocyanide ligand (11), and several [Rh(CNR)4]+ alkyl and aryl isocyanide complexes (R= Bu, Pr, /)-C6H4C1, /.-CSH4CH3, and P-C6H4OCH3) have... 

If RhCl3 SHjO and methyl isocyanide are reacted under mild conditions, and then 1 added, the rhodium(III) isocyanide complex Rh(CNCH3)3l3 is obtained (11). 

The hexakis(methyl isocyanide) dimers, [Pt2(CNMe)6], undergo photolytic cleavage of the Pt—Pt bond to give 15-electron radicals, Pt(CNMe)3.94 Mixtures of platinum and palladium dimers give rise to heteronuclear complexes under photolytic conditions. Mixtures of normal and deuterium-labeled methyl isocyanide complexes reveal that the metal-ligand bonds undergo thermal redistribution.94... 

The combination of a Mannich-3CR with an Ugi-4CR results in a seven-component reaction (7CR), as shown in Scheme 9.8. Reaction of dimethylamine, formaldehyde and isobutyraldehyde led to the 3-aminoaldehyde 9-40, which was treated with valine, methyl isocyanide, and methanol to give the anticipated product 9-41 [3],... 

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