Extractables toxicological evaluation

Kay, J.H., and J.C. Calandra. 1961. Unpublished report by industrial bio-test laboratories Cited in WHO. 1982. Annatto extracts. Toxicological evaluation of certain food additives. WHO Food Additives Series, No. 17. 

Peterson, S.A., Greene, J.C. and Miller, W.E. (1990) Toxicological evaluation of hazardous waste samples extracted with deionized water or sodium acetate (TCLP) leaching media, in D. Friedman (ed.), Waste Testing and Quality Assurance, ASTM STP 1062, Philadelphia, USA, 2, 107-129. 

Therefore, systematic and detailed investigations of plant constituents having hypoglycemic potential are very desirable and recommended. However, it is crucial that such studies must involve toxicological evaluations of crude extracts as well as purified compounds. Such studies could lead to newer and better agents for the treatment of diabetes. 

In summary, for uew classes of compouuds, the recommeudatiou is that either the situatiou may be ideutified (humau illuess outbreak, new species or strain of algae or new symptoms of toxicity in mouse test), toxicological evaluation of the crude toxin extracts made or, ideally, isolated toxic compound should be carried out in order to assess the risk before deciding not to regulate or set a tolerable level. 

Li, N., Zhang, Q., and Song, J. 2005. Toxicological evaluation of fucoidan extracted from Laminaria Japonica in Wistar rats. Food Chem. Toxicol. 43, 421 26. 

Ribnicky, D.M., A. Poulev, J. O Neal, et al. 2004. Toxicological evaluation of the ethanolic extract of Artemisia dracunculus L. for use as a dietary supplement and in functional foods. Food Chem. Toxicol. 42(4) 585-598. 

Lalithakumari, K, A.V. Krishnaraju, Sengupta, G.V. Subbaraju, and A. Chatterjee. 2006. Safety and toxicological evaluation of a novel, standardized 3-0-acetyl-ll-keto-(beta)-boswellic add (AKBA)-enriched Boswellia serrata extract (5-Loxin ). Toxicol. Mech. Methods 16(4) 199-226. 

Schmidt, B.M., N. lUc, A. Poulev, and I. Raskin. 2007. Toxicological evaluation of a chicory root extract. Food Chem. Toxicol. 45(7) 1131-1139. 

Qadri, N.M., S. Ahmad, S. Qureshi, and Y. Badar. 2001. Acute toxicological evaluation of the aqueous extract of Eclipta alba Hassk. Pakistan J. Sd. Ind. Res. 44(1) 38-41. 

Almeida, E.R., A.M. Melo, and H. Xavier. 2000. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother. Res. 14(2) 99-102. 

Keller, K.A., and D.L. Meyer. 1989. Reproductive and developmental toxicological evaluation of Sanguinaria extract. /. Clin. Dent. l(3) 59-66. 

Evaluation of food additives specifications for the identity and purity of food additives and their toxicological evaluation some extraction solvents and certain other substances and a review of the technological efficacy of some antimicrobial agents (Fourteenth report of the Joint FAO/WHO Expert Committee on Food Additives). FAO Nutrition Meetings Series, No. 48,1971 WHO Technical Report Series, No. 462,1971. Toxicological evaluation of some extraction solvents and certain other substances. FAO Nutrition Meetings Report Series, No. 48A, 1971 WHO/Food Add/70.39. Specifications for the identity and purity of some extraction solvents and certain other substances. FAO Nutrition Meetings Report Series, No. 48B, 1971 WHO/Food Add/ 70.40. 

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