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Translation mechanism

A wide body of data now supports the idea that infectious prions consist principally or entirely of an abnormal iso form of PrP. Disease associated PrP, designated PrPSc, is derived from PrPc by a post-translational mechanism and neither amino acid sequencing nor systematic study of known covalent post-translational modifications have shown any consistent differences between PrPc and PrIJSt [5,20]. [Pg.795]

In a manner similar to copper homeostasis, zinc homeostasis in mammals involves post-translational mechanisms. Both Zipl and Zip3 are found predominantly at the plasma... [Pg.149]

R. Giege M. Frugier, Transfert RNA Structure and Identity. In Translation Mechanisms J. Lapointe, L. Brakier-Gingras, Eds. Eurekah.com/Landes Bioscience Georgetown TX, 2003 pp 1-24. [Pg.424]

Additionally, the cellular location at which the resultant polypeptide will function often cannot be predicted from RNA detection/sequences nor can detailed information regarding how the polypeptide product s functional activity will be regulated (e.g. via post-translational mechanisms such as phosphorylation, partial proteolysis, etc.). Therefore, protein-based drug leads/targets are often more successfully identified by direct examination of the expressed protein complement of the cell, i.e. its proteome. Like the transcriptome (total cellular RNA content) and in contrast to the genome, the proteome is not static with changes in cellular... [Pg.49]

Higher plants produce two distinct MT-Iike polypeptides, gene-encoded proteins with similar properties to certain class I and II MTs, and PCs (class III MTs). The synthesis of both types of molecule is regulated by metal ions. PC synthase is directly activated by metal ions by a post-translational mechanism. The gene-encoded MTs have constitutive abundant mRNA levels in roots which may be repressible by metal-shock in some species. [Pg.20]

H. Makelt (R. Hardbottle, translator), Mechanical Presses , Edward Arnold, London, 1968. [Pg.308]

We next consider a more challenging problem, that of VER in neat liquid oxygen (where now the solute and solvent molecules are both oxygen). This is more challenging for two reasons (1) Whereas in the last problem VER was dominated by the vibration-translation mechanism, in this case since the solvent is molecular, and one can anticipate that VER will have contributions from both vibration-translation and vibration-rotation channels. This means that rotations of the solvent will have to be considered explicitly, and, for example, we will not be able to use the analytical results discussed above. (2) Whereas the last problem was nearly classical (kT Hvibrational frequency of oxygen, one is deeply in the quantum regime (hox, kT), and so the issue of the most appropriate semiclassical approximation scheme becomes very important. [Pg.694]

Hendrickson T, Schimmel P. Transfer RNA-dependent amino acid discrimination by aminoacyl-tRNA synthetases. In Translation Mechanisms. Lapointe J, Brakier-Gingras L, eds. 2003. Kluwer Academic/Plenum Publishers, New York. p. 34-64. [Pg.38]

Page EL, Robitaille GA, Pouyssegur J, Richard DE. 2002. Induction of hypoxia-inducible factor-la by transcriptional and translational mechanisms. J Biol Chem 277 48403-48409. [Pg.294]

Regulatory DNA-binding proteins are controlled by a multitude of mechanisms. These controls operate at the level of the concentration of the binding protein or they act on preexisting DNA-binding proteins by post-translational mechanisms. [Pg.20]


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See also in sourсe #XX -- [ Pg.872 ]




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MRNA translation, regulatory mechanism

Post-translational modifications mechanism

Protein translation mechanics

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Translational partition function and quantum mechanics

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