Ethyl 4-formyl-2-methyl

Oxidation of one molar proportion with sodium pieriodate produces two equivalents of formic acid, in accordance with the existence of hydroxyl groups attached to four contiguous carbon atoms. This oxidation (and also that carried out with lead tetraacetate) gives an aldehyde, whose semicar-bazone has an analysis corresponding to that of the semicarbazone of an ethyl formyl-methyl-furoate (XII). By oxidation of aldehyde XII with silver oxide in alkaline solution, 2-methyl-3,4-furandicarboxylic acid (XIV) was obtained this was identical with the compound described by Alder and Rickert.20 The identity was confirmed by preparation of the respective dianilides. The acid XIV has also been prepared by the reaction between the sodium salt of ethyl acetoacetate and ethyl bromopyruvate.9... 

Similarly, ethyl (or methyl) a-formyl chloroacetate (69), Rj = H, and its substituted derivatives, condensed with thioformamide or higher thioamides give 5-ethyl- or 5-rnethyl-thiazole carboxylates (70) in good... 

N-Heterocycles Pyridine Pyrazines Unsubstituted, 2,3-Dimethyl, MARM ++ 2,5-Dimethyl-3-ethyl, Methyl, 2-Ethyl-6-methyl, 2,5-Dimethyl, 2-Ethyl-5-methyl, 2,6-Dimethyl, Acetylmethyl, 2-(2-Furyl), Ethyl, 2-Methyl-5-(methylethyl), Trimethyl Pyrroles 2-Acetyl, N-Methyl-2-furyl, 1-Formyl, 1-Furfury 1-2-formyl, 5-Methvl-2-formvl Trimethylpyrazine (TMPy) (RV = 0.989)... 

Vilsmeier reaction of ethyl 1 -methyl-4/f-pyrrolo[3,2- ]pyrrole-2-carboxylate (72) gave a mixture of C-5 (73) and C-6 (74) formylated products <89TL1655>. 

Methan (Benzyl-ethyl-amino)-(formyl-methyl-amino)- E14a/3, 563 (CH20 + HjC-NH-CHO/SOCl2 R2NH) 1,2,5-Oxadiazin 5-Phenyl-2-propyl-tetrahydro- E16a, 312 (aus Imidazolidin)... 

Benzol 3-Acetamino-2-(formyl-methyl)-l -(2-methoxy-2-hydro-peroxy-ethyl)- IV/la, 31 Bernsteinsaure 2-(N-Benzyl-... 

Ethyl 2-methyl-4-(D-ara6mo-tetrahydroxybutyl)pyrrole-3-carbothiolate (18) yields a tetra-O-acetyl derivative, and, on oxidation with periodic acid, affords ethyl 4-formyl-2-methylpyrrole-3-carbothiolate (22). Lactone (27) gives a tri-O-acetyl derivative and, on alkaline hydrolysis, consumes one equivalent of base and furnishes 2-methyl-4-(D-arofemo-tetrahydroxy-butyl)pyrrole-3-carboxylic acid (19) in almost quantitative yield. This acid can, in turn, be transformed into a tetra-O-acetyl derivative, and, when oxidized with sodium metaperiodate, it gives 4-formyl-2-methyl-pyrrole-3-carboxylic acid (23). Attempts to determine the size of the lactone ring in compound (27) by oxidation with sodium metaperiodate were unsuccessful three moles of metaperiodate were consumed per mole, as if, during the oxidation, hydrolysis of the lactone had occurred. 

Other AB building blocks were also synthesized from aldehyde 72 by transformation of the formyl group into hydroxymethyl, ethyl, and methyl groups. 

CAS 6272-74-8 EINECS/ELINCS 228-464-1 Synonyms N-(Acylcolaminoformulmethyl) pyridinium chloride 1-(2-Hydroxyethyl)carbamoyl methyl pyridinium chloride laurate N-(Lauryl colamino formyl methyl) pyridinium chloride 1-[2-Oxo-2-[[2-[(1-oxododecyl) oxy] ethyl] amino] ethyl] pyridinium chloride Pyridinium, 1-(2-hydroxyethylcarbamoylmethyl)-, chloride, dodecanoate... 

N-(Lauryl colamino formyl methyl) pyridinium chloride. See Lapyrium chloride Lauryl diethanolamide. See Lauramide DEA Lauryl diethylenediaminoglycine CAS 6843-97-6 EINECS/ELINCS 229-930-7 Synonyms N-[2-[[-(Dodecylamino) ethyl] amino] ethyl] glycine Dodicin Glycine, N-[2-[[2-(dodecylamino) ethyl] amino] ethyl]-Classification Substituted amino acid Empirical C18H39N3O2 Formula ... 

Pterin, 6,7-dimethyl-5,6,7,8-tetrahydro-configuration, 3, 281 conformation, 3, 281 Pterin, 6,7-diphenyl-chlorination, 3, 296 methylation, 3, 297 reduction, 3, 307 Pterin, 6,7-diphenyl-5,6-dihydro-properties, 3, 306 UV spectrum, 3, 279 Pterin, 6-ethyl-5,6,7,8-tetrahydro-configuration, 3, 281 Pterin, 6-formyl-synthesis, 3, 318 Pterin, 6-formyl-5,8-dihydro-synthesis, 3, 306... 

Pyrimidine, 2-ethyl-1,4,5,6-tetrahydro-synthesis, 3, 108 Pyrimidine, 5-formyl-2-methyl-in thiamin biosynthesis, 1, 99 Pyrimidine, fluoro-syhthesis, 3, 140 Pyrimidine, 2-fluoro-NMR, 3, 63 synthesis, 3, 140 Pyriihidine, 4-fluoro-synthesis, 3, 140 Pyrimidine, 6-fluoro-synthesis, 3, 140 Pyrimidine, fluoroalkyl-synthesis, 3, 77... 

Pyrrole-3-carboxylic acid, 2,5-dimethyl-ethyl ester formylation, 4, 217 Pyrrole-3-carboxylic acid, 2-methyl-ethyl ester... 

Selective formylation of the 3,20-diketone (1) with ethyl formate gives the 2-hydroxymethylene ketone (2). Subsequent methylation and acidic de-formylation affords the 2a-monomethyl product (4) in 50% yield. 

This activation of the ortho position is most strikingly illustrated in the reactivity of 2,5-dimethylthiophene, which competitive experiments have shown to undergo the SnCb-catalyzed Friedel-Crafts reaction more rapidly than thiophene and even 2-methylthiophene. The influence of the reagent on the isomer distribution is evident from the fact that 2-methoxythiophene is formylated and bromi-nated (with A -bromosuccinimide) only in the 5-position. Similarly, although 3-bromo-2-methylthiophene has been detected in the bromi-nation of 2-methylthiophene with bromine, only the 5-isomer (besides some side-chain bromination) is obtained in the bromination of alkylthiophenes with A -bromosuccinimide. ° However, the mechanism of the latter type of bromination is not established. No lines attributable to 2-methyl-3-thiocyanothiophene or 2-methyl-3-chIoro-thiophene could be detected in the NMR spectra of the substitution products (5-isomers) obtained upon thiocyanation with thiocyanogen or chlorination with sulfuryl chloride. 2-Methyl- and 2-ethyl-thiophene give, somewhat unexpectedly, upon alkylation with t-butyl chloride in the presence of Feds, only 5-t-butyl monosubstituted and... 

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