Ethinyl testosterone

Danazol is an isoxazole derivative of 17alpha-ethinyl testosterone. It has weak androgenic activity. It inhibits gonadotrophin secretion and is used to suppress ovarian function. It induces endometrial atrophy and has found its major use in the management of endometriosis. Gestrinon has the same indication and acts via a similar mechanism. Danazol has also been used in the management of benign breast disorders such as fibrocystic disease. 

It is an isoxazole derivative of ethisterone (17a-ethinyl testosterone) with weak... 

Synonyms. Aethisteron Anhydrohydroxyprogesterone Ethinyl-testosterone Praegnin Pregneninolone Pregnin. 

Names synonyms DIMETHISTERONE 6a.21 -dimethylethisterone 6a,21 -dimethyl 17 hydroxy-17a-pregn 4-en-20 yn 3-one 6a methyM7a propynylandrost 4 en l7/ ol 3 one 17 -hydroxy 6 -methyl 17a-(prop-1 ynyl) androst-4-cnc-3-one. ETHISTERONE anhydrohydroxyprogesterone ethinyl testosterone pregneninolone 17a ethynyl testosterone 17a-ethynyl-l 7 -hydroxy-4-androsten-3-one. ETHYNODIOL DIACETATE 17a-ethynyl-4-e trene-3. 17/l-dioI-l 7 diacetate I9-nor-17a-pregn-4-en-20 yne-3. 17-diol diacetate. 

In 1957 Carol published a short review on the application of infrared methods to pharmaceutical analysis. Among the substances for which infrared methods had been developed at that time he mentioned atropine, nitroglycerine, sodium A-lauroyl sarcosinate, phenobarbital, testosterone, and progesterone. Other substances for which analytical methods were given were penicillin G in the presence of penicillin F, K, or dihydro-F ethinyl testosterone aspirin, phenacetin, and caffeine and estrogenic substances, e.g., estrone, equilin, and estradiol-17-/J (cis). 

A4 Acetaminophen, alfentanil, amiodarone, astemizole, cocaine, cortisol, cyclosporine, dapsone, diazepam, dihydroergotamine, dihydropyridines, diltiazem, ethinyl estradiol, gestodene, indinavir, lidocaine, lovastatin, macrolides, methadone, miconazole, midazolam, mifepristone (RU 486), paclitaxel, progesterone, quinidine, rapamycin, ritonavir, saquinavir, spironolactone, sulfamethoxazole, sufentanil, tacrolimus, tamoxifen, terfenadine, testosterone, tetrahydro-cannabinol, triazolam, troleandomycin, verapamil Barbiturates, carbamazepine, macrolides, glucocorticoids, pioglitazone, phenytoin, rifampin Erythromycin, 613-hydroxy cortisol... 

SYNS 17-a-ETHINYLESTRA-4-EN-17-p-OL-3-ONE 17-a-ETHINYL-17-P-HYDROXY-Ai4-ESTREN-3-ONE 17-a-ETHINYL-19-NORTESTOSTERONE 17-a-ETHYNYL-4-ESTREN-17-OL-3-ONE 17-a-ETHYNYL-17-HYDROXY 4-ESTREN-3-ONE 17-a-ETHYNYL-17-p-HYDROXY-19-NORANDROST-4-EN-3-ONE 17-a-ETHYNYL-19-NORANDROST-4-EN-17-P-OL-3-ONE 17-a-ETHYNYI 19-NOR-4-ANDROSTEN-17-P-OL-3-ONE 17-a-ETHYNYL-19-NORTESTOSTERONE (17-a)-17-HYDROXY-19-NORPREGN-4-EN-20-YN-3-ONE 17- 3-HYDROXY-19-NORPREGN-4-EN-20-YN-3-ONE 17-HYDROXY-19-NOR-17-a-PREGN-4-EN-20-YN-3-ONE 19-NOR-ETHINYL-4,5-TESTOSTERONE 19-NOR-17-0-ETHYNYLANDROSTEN-17-P-OL-3-ONE 19-NOR-17-a-ETHYNYL-17-P-HYDROXY-4-ANDROSTEN-3-ONE 19-NOR-17-a-ETHYNYLTESTOSTERONE NORLUTIN... 

The steroids as a group tend to be poorly soluble in water. Their complex stmcture makes prediction of solubility somewhat difficult, but one can generally rationalise, post hoc, the solubility values of related steroids. Table 5.6 gives solubility data for 14 steroids. As examples, the substitution of an ethinyl group has conferred increased solubility on the estradiol molecule, as would be expected. Estradiol benzoate with its 3-OH substituent is much less soluble than the parent estradiol because of the loss of the hydroxyl and its substitution with a hydrophobic group. The same relationships are seen in testosterone and testosterone propionate. As both estradiol benzoate and testosterone propionate are oil soluble, they are used as solutions in castor oil and sesame oil for intramuscular and subcutaneous injection (see Chapter 9). 

Norethynodrel, I7-a-ethinyl-17p-hj roxy-5(10)-estrene-3-one, increases eidrenal wei ts in intact female rats59. plasma and adrenal B levels decrease at the time of day dien values are normally highest. Clomiphene increases output of 17-oxysteroids in a patient with galactorrhea Cyano-trimethylandrostenolone, 2a-cyano-J4-, k, 17a-trimethyl-17p -OH- 5-androstene- 3-one, causes adrenal hypertrophy, a fall in adrenal venous 3 of male rats and inhibition of 3P-hydroxysteroid dehydrogenase l. Norethandrolone, 170(-ethyl-17P-0H- -norandrostene-3-one, stimulates the production of B by adrenals of castrated rats and increases pituitary ACTH content . This androgen partially reverses the E induced suppression of B production but not of the adrenal response to stresses. Testosterone, androstenedione, EHEA, estrone and estradiol has no effect on conversion of B to 18-OH B and Aldo by sheep adrenal mitochondria . 

Simultaneous acetaminophen, aldosterone, allopurinol, amitriplyline, caffeine, calcitriol, cephalothin, chlordiazepoxide, chlorothiazide, corticosterone, cortisone, dexamethasone, diazepam, ephedrine, ethinyl estradiol, furosemide, hydrocortisone, ibuprofen, imipra-mine, indomethacin, mechlorethamine, methylprednisone, metolazone, nandrolone, naproxen, phenacetin, phenobarbital, phen3doin, probenecid, progesterone, propranolol, sulfasalazine, testosterone, theophylline, vincristine... 

Also analyzed androsterone (UV 210), cortexolone, cortisone, estradiol (UV 280), estrone (TJV 280), ethinyl estradiol (UV 280), ethisterone, hydrocortisone, hydroig progesterone, lynestrenol (UV 210), medroxyprogesterone acetate, medroxyprogesterone, methandi-enone, methylandrostenediol (UV 210), methylprednisolone acetate, methylprednisolone, methyltestosterone, nandrolone, norethisterone, prednisolone acetate, prednisolone, pregnenolone (UV 210), progesterone, testosterone... 

Androgens with an alkyl group (ethinyl- or methyl-) added to carbon-17 of the steroid nucleus are likely to have which property relative to natural testosterone ... 

The FDA has approved a triphasic, low-dose combination oral contraceptive (ortho tri-cyclen) containing ethinyl estradiol and norgestimate for the treatment of moderate acne vulgaris. Similar preparations (demulen 1/35, DESOGEN, others) also are effective. The mechanism appears to be a decrease in free plasma testosterone due to an increase in plasma SHBG. 

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