Estrogens growth activity

Among the known sequelae of exposure to chlorinated organics in mammals is that of estrogen-like activity (ref. 8 ). DDT inhibition of testicular growth and secondary sex characteristics development in white... 

Filardo, E.J., Quinn, J.A., Bland, K.I. and Frackelton, A.R. (2000) Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Molecular Endocrinology, 14, 1649-1660. 

Rootlet total saponins have been shown to promote growth in mice and to have androgenic activities in rats. ° Ginsenoside Rgi, on the other hand, was found to possess in vitro estrogen-like activity in MCF-7 cells. ... 

Many stilbenelike thiophene compounds have been prepared for a study of estrogenic activity, especially by Buu-Hoi et al. Thiophene derivatives of nonhydroxylated stilbene types showed no significant activitywhereas weak estrogenic activity was found in 5-acetyl-, 5-propionyl-, and 5-benzoyl-2-(-stilbenyl)thiophene. 1-Bromo-l,2-diphenyl-2-(5-bromo-2-thienyl)ethylene (258) was found to inhibit body growth and to produce extensive testicular atropy in male rats. A thiophene analog of estrogenic isoflavones (259)... 

Cells from tissues associated with primary and secondary sexual characteristics are under particular endocrine control. Sex hormones determinethe growth, differentiation, and proliferation of such cells. When a tumor develops in such tissues, it is sometimes hormone dependent and the use of anti hormones removes the impetus for the tumor s headlong growth. Many nonsteroidal compounds have estrogenic activity diethylstilbest-jrol (81) may be taken as an example. Certain more bulky an-... 

Tibaduiza, E.C. et al., Excentric cleavage products of beta-carotene inhibit estrogen receptor positive and negative breast tumor cell growth in vitro and inhibit activator protein-1-mediated transcriptional activation, J. Nutr., 132, 1368, 2002. 

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