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Esters acid, formation

Hydroxamic acid formation cf. Section 9, p. 334). To a few drops of an ester, add 0 2 g. of hydroxylamine hydrochloride and about 5 ml. of 10% NaOH solution and gently boil the mixture for 1-2 minutes. Cool and acidify with dil. HCl and then add a few drops of ferric chloride solution. A violet or deep red-brown colour develops immediately. [Pg.355]

The success of the last reaction depends upon the inertness of the ester carbonyl groups towards the organocadmium compound with its aid and the use of various ester acid chlorides, a carbon chain can be built up to any reasonable length whilst retaining a reactive functional group (the ester group) at one end of the chain. Experimental details are given for l-chloro-2-hexanone and propiophenone. The complete reaction (formation of ketones or keto-esters) can be carried out in one flask without isolation of intermediates, so that the preparation is really equivalent to one step. [Pg.936]

Formulations for acryHc copolymers involve monomers such as acryHc acid [79-10-7], methacrylic acid [79-14 ], or esters of these acids. Formation of a copolymer from a methylmethacrylate ester (3), where DVB serves as the cross-linker, gives the stmctures ... [Pg.373]

The mandelic acid formate ester obtained as a syrup as described above Is stirred for 2 hours with 2.9 kg ( 1.75 ) of thionyl chlorideat a temperature of about 70°C. The excess thionyI chloride is removed by evaporation and the residual green solution is vacuum distilled. The product, 0-formyl mandeloyl chloride, distills over at 127°C to 130°C (15 mm) or at 108°C to 112°C (7 mm). [Pg.262]

The net effect of Fischer esterification is substitution of an -OH group by —OR. Aii steps are reversible, and the reaction can be driven in either direction by choice of reaction conditions. Ester formation is favored when a large excess of alcohol is used as solvent, but carboxylic acid formation is favored when a large excess of water is present. [Pg.796]

The reagent (1) is easily made from thiol (3) and ethylene oxide or 2-chloroethanol (2). The acid RCOgH is then protected by acid-catalysed ester (4) formation. [Pg.84]

Alternative paths for decomposition of the metal carboxylate can lead to ketones, acid anhydrides, esters, acid fluorides (1,11,22,68,77,78), and various coupling products (21,77,78), and aspects of these reactions have been reviewed (1,11). Competition from these routes is often substantial when thermal decomposition is carried out in the absence of a solvent (Section III,D), and their formation is attributable to homolytic pathways (11,21,77,78). Other alternative paths are reductive elimination rather than metal-carbon bond formation [Eq. (36)] (Section III,B) and formation of metal-oxygen rather than metal-carbon bonded compounds [e.g., Eqs. (107) (119) and (108) (120). Reactions (36) and (108) are reversible, and C02 activation (116) is involved in the reverse reactions (48,120). [Pg.267]

The formation of relatively ill-defined catalysts for epoxide/C02 copolymerization catalysts, arising from the treatment of ZnO with acid anhydrides or monoesters of dicarboxylic acids, has been described in a patent disclosure.968 Employing the perfluoroalkyl ester acid (342) renders the catalyst soluble in supercritical C02.969 At 110°C and 2,000 psi this catalyst mixture performs similarly to the zinc bisphenolates, producing a 96 4 ratio of polycarbonate polyether linkages, with a turnover of 440 g polymer/g [Zn] and a broad polydispersity (Mw/Mn>4). Related aluminum complexes have also been studied and (343) was found to be particularly active. However, selectivity is poor, with a ratio of 1 3.6 polycarbonate polyether.970... [Pg.56]

The reaction of tert-butyl esters with Et3SiH/TFA results in the reductive deprotection of the ester and formation of isobutane. The yields of the isobutane are not recorded, but the acids are obtained nearly quantitatively (Eq. 150).307 In a similar manner, the lactone shown in Eq. 151 is converted into the acid in good yield.308 In like manner, the reductive deprotection of allyl esters provides the carboxylic acids in high yields.270... [Pg.55]

Plumb, J.B., Obrycki, R., and Griffith, C.E., Phosphonic acids and esters. XVI. Formation of dialkyl phenylphosphonates by the photoinitiated phenylation of trialkyl phosphites, ]. Org. Chem., 31, 2455, 1966. [Pg.182]

C domains can display functions that deviate from typical amide bond formation. Several C domains are postulated to act as ester synthases, catalyzing ester formation instead of amide formation. NRPS modules containing C domains that display this activity are present in the biosynthetic pathways for the kutznerides, cryptophycins, " cereulide, valinomycin, hectochlorin, and beauvericin. Each of these C domains likely utilizes a PCP-bound a-hydroxyl acceptor in the condensation reaction. Another NRPS C domain that catalyzes ester bond formation is involved in the biosynthesis of the polyketide-derived mycotoxins known as the fiimonisins. Du and coworkers have shown that a recombinant PCP-C didomain of an NRPS involved in the biosynthetic pathway of the fnmonisins can catalyze ester bond formation between hydroxyfumonisins and the A-acetylcysteamine thioester of tricarballylic acid, even though PCP-bound tricarballylic acid is not... [Pg.632]

The different carbosilane dendrimer supports (generation 0, 1 R=H, Me) were then used for the synthesis of the / -lactam (13). As shown in Scheme 7.2, the first step was again an immobilization of a carboxylic acid via ester bond formation. Treatment with LDA and ZnCl2 yielded in situ the corresponding zinc ester enolate (11) which reacts with N-(trimethylsilyl)phenylimine (12) to form the final four membered lactam ring (13). The last reaction step includes several intermediates. The last one is a supported /9-amino ester which undergoes spontaneous... [Pg.314]

One role of high density lipoprotein (HDL) is to collect unesterified cholesterol from cells, including endothelial cells of the artery walls, and return it to the liver where it can not only inhibit cholesterol synthesis but also provide the precursor for bile acid formation. The process is known as reverse cholesterol transfer and its overall effect is to lower the amount of cholesterol in cells and in the blood. Even an excessive intracellular level of cholesterol can be lowered by this reverse transfer process (Figure 22.10). Unfortunately, the level of HDL in the subendothelial space of the arteries is very low, so that this safety valve is not available and all the cholesterol in this space is taken up by the macrophage to form cholesteryl ester. This is then locked within the macrophage (i.e. not available to HDL) and causes damage and then death of the cells, as described above. [Pg.519]

The classes of compounds which are conveniently considered together as derivatives of carboxylic acids include the carboxylic acid anhydrides, acyl chlorides, esters, and amides. In the case of simple aliphatic and aromatic acids, synthetic transformations among these derivatives are usually a straightforward matter involving such fundamental reactions as ester saponification, formation of acyl chlorides, and the reactions of amines with acid anhydrides or acyl chlorides ... [Pg.164]

Whereas the Markovnikov addition of carboxylic acids to propargylic alcohols produces P-ketoesters, resulting from intramolecular transesterification [30, 31], the addition to propargylic alcohols in the presence of Ru(methallyl)2(dppe) 1 at 65 °C leads to hydroxylated alk-l-en-l-yl esters via formation of a hydroxy vinylidene intermediate [32, 33]. The stereoselectivities are lo ver than those obtained from non-hydroxylated substrates. These esters, which are protected forms of aldehydes, can easily be cleaved under thermal or acidic conditions to give conjugated enals, corresponding to the formal isomerization products of the starting alcohols (Scheme 10.6). [Pg.318]

There are many important [5 + 1] two-bond formation heterocyclic syntheses and in certain instances this approach constitutes the method of choice for the preparation of particular classes of heterocycle. Where a carbon atom constitutes the one-atom fragment it is almost invariably present in the form of an electrophilic species such as an aldehyde, carboxylic acid, ketone, ester, acid chloride, urea, etc., and fundamentally condensation consists of reaction of this electrophilic species with a 1,5-dinucleophilic reagent. Where the one-atom fragment is either nitrogen, oxygen or sulfur then the heteroatom may function either as a nucleophile or, in the case of nitrogen and sulfur, also as an electrophile. Almost... [Pg.75]

Some of the versions of the mixed anhydride technique discussed may involve components other than a-hydroxy acids. Therefore, the resultant products cannot be considered as main-chain modified peptidomimetics. However, on many grounds these methods are of general importance in depsipeptide synthesis. For example the classical peptide reagent isobutyl chloroformate appears to be suitable for ester bond formation through the corresponding mixed anhydride with Boc- or Z-protected amino acids and the Thr (3-hydroxy group in the synthesis of a number of natural peptide lactones.145 7 ... [Pg.276]

In addition to the more or less popular methods of depsipeptide synthesis discussed vide supra, there are also a limited number of complementary and effective synthetic procedures that have been described for this purpose. Among these, the well-known method of symmetric anhydrides from N-protected amino acids has to be considered. This method has found successful use in the esterification of hydroxy acids in the presence of some catalyst additives. Initially, the addition of pyridine11091 or 1-hydroxybenzotriazole in pyridine1 101 to a symmetric anhydride was utilized for ester bond formation. As an example, Katakai has prepared a number of didepsipeptides in 85-96% yield by means of a 2-nitrophenylsulfenyl /V-carboxy anhydride with lactic acid derivatives in the presence of pyridine.1 09 ... [Pg.285]


See other pages where Esters acid, formation is mentioned: [Pg.62]    [Pg.360]    [Pg.510]    [Pg.903]    [Pg.278]    [Pg.903]    [Pg.360]    [Pg.243]    [Pg.802]    [Pg.241]    [Pg.112]    [Pg.158]    [Pg.456]    [Pg.55]    [Pg.545]    [Pg.546]    [Pg.23]    [Pg.73]    [Pg.262]    [Pg.262]    [Pg.545]    [Pg.546]    [Pg.360]    [Pg.7]    [Pg.7]    [Pg.277]    [Pg.278]    [Pg.284]    [Pg.288]   
See also in sourсe #XX -- [ Pg.351 ]




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Esters Formates

Formate esters

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