Erythromycin gel

Dissolve item 4, mix with item 5, and cool when the air bubbles escape. 

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Oztiirkcan S, Ermertcan AT, Sahin MT, Afar FS (2004) Efficiency of benzoyl peroxide-erythromycin gel in comparison with metronidazole gel in the treatment of acne rosacea. J Dermatol 31 610-617... 

For example in the alcoholic erythromycin gel (Table 12.36) erythromycin is dissolved in ethanol first. Hypromellose has to be dispersed in this water free solution. Finally water and glycerol 85 % are added and the gelling agent starts to swell. The gel can be prepared in a flask because it is relatively thin. Substances that are insoluble in water such as corticosteroids and metronidazole are dispersed in an equal volume of gel and subsequently geometrically mixed with the rest of the base. 

Chepkwony, H., Vanderriest, I., Nguyo, ]., Roets, E., and Hoogmartens, J., Separation of erythromycin and related substances on base-deactivated re-versed-phase silica gel columns, /. Chromatogr. A, 870 (1 2), 227, 2000. 

Topical erythromycin formulations include a gel, lotion, solution, and disposable pads that are usually applied twice daily. 

Our laboratories10 have developed a system separating erythromycin estolate, erythromycin base, and anhydroerythromycin on a silica gel 60 F-254 plate utilizing ethanol, methanol, triethylamine, 170 30 1. Visualization is made by spraying with 0.15% xanthydrol and 7.5% acetic acid in water. Table V summarizes the Rf s. 

Z. H. Hash22 reported chromatographic conditions for separating anhydroerythromycin from erythromycin using a normal phase Corasil II silica gel column, with chloroform as mobile phase and refractive index detection. 

Eryfhramycin Benzoyl Peroxide (Benzamycin) [Anti-intective/ Macrolide/Keratolytic] Uses Topical for acne vulgaris Action Macrolide antibiotic w/ keratolytic Dose Apply bid (am pm) Caution [C, ] Contra Component sensitivity Disp Gel SE Local irritation, dryness EMS See Erythromycin OD Unlikely... 

In traditional electrophoresis, separation efficiency is limited by thermal diffusion and convection. Owing to long analysis times and low efficiencies, these procedures never enjoyed wide usage. Problems have arisen when trying to differentiate between structurally related drug residues such as streptomycin and dihydrostreptomycin, tetracyclines, lincomycin and clindamycin, and erythromycin and oleandomycin (83, 84). To overcome these problems, anticonvective media, such as polyacrylamide or agarose gels, have also been used. 

Erythromycin, Animal MeOH extn, liq-liq 14 Silica gel CHCls/MeOH/ B. subtilis bio- 1 -20 ppm/ 14... 

Erythromycin and benzoyl peroxide topical gel Drug product... 

In 11 healthy men, erythromycin 250 mg qds increased the AUC of saquinavir (given as a soft gel capsule 1200 mg tds) by 69% when both were given for 7 days (18). 

Aldol reaction of (5)-2-benzyloxypropanal with the lithium enolate of methyl 2-methoxy-propanoate gives a 7 2 1 mixture of (3-hydroxyesters (Scheme 13.70). After protection of the alcohol moiety, the isomeric mixture is reduced with LiAlH4 and the resulting primary alcohols separated by chromatography on silica gel. Oxidation of the major alcohol 223 (isolated in 40% yield) into an aldehyde is followed by Wittig methylenation. This provides 224. Hydroboration of 224 gives a primary alcohol that is oxidized (Swem) into aldehyde 225. Hydrogenation yields L-cladinose, a saccharide moiety of erythromycin A [127]. 

Erythromycin and erythromycin estolate can be separated and quantitated by thin layer chromatography.Samples or standards should approximate 50 meg erythromycin estolate and 5-10 meg erythromycin base when spotted on silica gel G-25 plates. Approximately 120 ml of the developing solvent (methanol A.R.) is placed into the developing tank and allowed to equilibrate. The plate is developed until the solvent is approximately 15 cm from the origin The plate is removed and allowed to air dry. Antibiotic spots are visualized by spraying the plate with a fresh mixture of 95 ethanol/anis-aldehyde/conc. sulfuric acid, 90 5 5(v/v) followed by heating of the plate at 110 C for 10 minutes. The Rf values of erythromycin estolate and erythromycin base are approximately 0.7 and 0.35 respectively. 

Topical erythromycin, usually applied twice daily, is formulated as a gel, lotion, solution, and disposable pad. Reduction of the percentage of free fatty acids in sebum has been noted with the use of topical erythromycin. ... 

After topical application of retinaldehyde 0.1% gel or its vehicle every morning and erythromycin 4% lotion every evening in the treatment of acne for 8 weeks, comedones and microcysts were significantly improved with retinaldehyde combined with erythromycin, but not with erythromycin alone. In both treatment groups, papules and pusmles were reduced significantly. Local tolerance is satisfactory. ... 

Resistant strains of P. acnes are emerging that may respond to jndicions nse of retinoids in combination with antibiotics. Commonly nsed topical antimicrobials in acne inclnde erythromycin, clindamycin (Cleocin-t), and benzoyl peroxide and antibiotic-benzoyl peroxide combinations (Benzamycin, Benzaclin, others). Other antimiaobials nsed in treating acne inclnde sulfacetamide (Klaron), sulfacetamide/sulfur combinations (Snlfacet-R), metronidawie (Metrocream, Metro-Gel, noritate), and azelaic acid (Azelex). Systemic therapy is prescribed for patients with more extensive disease and acne that is resistant to topical therapy. Effective agents inclnde tetracycline (snmycin, others), minocycline (MINO-CIN, others), erythromycin (ERYC, others), clindamycin (CLEOCIN), and trimethoprim-sulfamethoxazole (bactrim, others). Antibiotics nsnally are administered twice daily, and doses are tapered after control is achieved. 

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