Epithelial permeability

Kubes, P. (1992). Nitric oxide modulates epithelial permeability in the feline small intestine. Gastroenterology 102, A219. [Pg.166]

RM Effros, GR Mason. Measurements of pulmonary epithelial permeability in vivo. Am Rev Respir Dis 125 S59-S65, 1983. [Pg.500]

Borchardt. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology 1989, 96, 736—749... [Pg.82]

The rat intestinal cell line IEC-18 has been evaluated as a model to study small intestinal epithelial permeability. This cell line forms very leaky monolayers with TER of 50 n cm2 and permeability to mannitol of 8 x 10-6 cm s 1. The IEC-18 model was proposed to be a better model than the Caco-2 monolayers for evaluating the small intestinal paracellular permeation of hydrophilic molecules. However, the leakier paracellular pathway is related to the poor differentiation level of the cells and an undeveloped paracellular barrier lacking peri-junctional actin-belt. In addition, due to the poor differentiation the cells have minute expression of transporters and are therefore not useful for studies of carrier-mediated transport [82, 84]... [Pg.99]

Animal studies indicate that the pathogenesis of NSAID small intestinal toxicity involves multiple interactions dependent on enterohepatic circulation, epithelial permeability, neutrophil infiltration and bacterial infection [233]. Several investigations [234-238] have suggested that bacterial flora may play a role in the pathogenesis of NSAID bowel injury and Robert and Asano [239] did show more than 25 years ago that germ-free rats are resis-... [Pg.56]

Single injection of ultrafine particles of nickel metal (20 nm diameter) at 5 mg Severe lung inflammation, cytotoxicity, and increased epithelial permeability 42... [Pg.507]

Jacobsen J, Brpndum-Nielsen K, Christensen ME, Olin H-BD, Tommerup N, Rassing MR (1999) Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability. Eur J Oral Sci 107 138-146... [Pg.105]

An increased epithelial permeability of hydrophilic compounds, that is terbutaline (Mw 225 Da), 99mTc-labelled diethylene triamine penta-acetate (99mTc-DTPA Mw 492 Da), 113mln-labelled biotinylated DTPA (Mw 1,215 Da) and insulin, has been demonstrated in smokers as compared to non-smokers [8, 62, 84, 127, 159],... [Pg.140]

Folkesson HG, Westrom BR, Karlsson BW (1998) Effects of systemic and local immunization on alveolar epithelial permeability to protein in the rat. Am J Respir Crit Care Med 157 324-327. [Pg.157]

Jones JG, Minty BD, Lawler P, Hulands G, Crawley JC, Veall N (1980) Increased alveolar epithelial permeability in cigarette smokers. Lancet 1 66-68. [Pg.158]

O Byrne PM, Dolovich M, Dirks R, Roberts RS, Newhouse MT (1984) Lung epithelial permeability relation to non-specific airway responsiveness. J Appl Physiol 57 77-84. [Pg.160]

Winton HL, Wan H, Cannell MB, Gruenert DC, Thompson PJ, Garrod DR, Stewart GA, Robinson C (1998) Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability. Clin Exp Allergy 28 1273-1285. [Pg.163]

Soderholm JD, Holmgren Petersson K, Olaison G, Franzen LE, Westrom B, Magnusson KE, Sjodahl R (1999) Epithelial permeability to proteins in the non-inflamed ileum of Crohn s disease Gastroenterology 117 65-72. [Pg.213]

In vitro cell culture models of human nasal epithelium based on primary culture technologies have proven to be extremely useful for mechanistic studies of nasal epithelial permeability and drug absorption [13]. However, efforts... [Pg.217]

Gorodeski GI [2000] Role of nitric oxide and cGMP in the estrogen regulation of cervical epithelial permeability. Endocrinology 141 1658-1666... [Pg.359]

Gorodeski GI [2000] Effects of menopause and estrogen on cervical epithelial permeability. J Clin Endocrinol Metab 85 2584-2595... [Pg.359]

Gorodeski GI [2000] Vaginal—Cervical epithelial permeability decreases after menopause. Fertil Steril 76 753-761... [Pg.359]

Gorodeski GI [2005] Aging and estrogen effects on transcervical—transvaginal epithelial permeability. J Clin Endocrinol Metab 90 345-351... [Pg.360]

Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations... [Pg.430]

The smallest functional unit of the kidney is the nephron. In the glomerular capillary loops, ultrafiltration of plasma fluid into Bowman s capsule (BC) yields primary urine. In the proximal tubules (pT), approx. 70% of the ultrafiltrate is retrieved by isoosmotic reabsorption of NaCl and water. In the thick portion of the ascending limb of Henle s loop (HL), NaCl is absorbed unaccompanied by water. This is the prerequisite for the hairpin countercurrent mechanism that allows build-up of a very high NaQ concentration in the renal medulla In the distal tubules (dT), NaCl and water are again jointly reabsorbed. At the end of the nephron, this process involves an aldosterone-controlled exchange of Na+ against 1C or H. In the collecting tubule (C), vasopressin (antidiuretic hormone, ADH) increases the epithelial permeability for water, which is drawn into the hyperosmolar milieu of the renal medulla and thus retained in the body. As a result, a concentrated urine enters the renal pelvis. [Pg.160]

Other portions of the gastrointestinal tract can also be injured. Chronic alcohol ingestion is by far the most common cause of chronic pancreatitis in the Western world. In addition to its direct toxic effect on pancreatic acinar cells, alcohol alters pancreatic epithelial permeability and promotes the formation of protein plugs and calcium carbonate-containing stones. [Pg.496]

Dodane, V., M. Amin Khan, and J.R. Merwin. 1999. Effect of chitosan on epithelial permeability and structure. Int J Pharm 182 21. [Pg.52]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...