In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations

Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations 

Stephan A. Motz, Michael Bur, Ulrich F. Schaefer, and Claus-Michael Lehr 

The second part describes different experimental approaches to simultaneously assess deposition and subsequent absorption of pharmaceutical aerosol formulations, typically by adapting some existing impactor/impinger devices to accommodate pulmonary epithelial cell culture systems. Differences between longtime and low-dose aerosol deposition in environmental toxicology and short time bolus inhalation of pharmaceutical aerosols are elucidated. 

Keywords Dissolution Permeability Dosage forms Bioavailability Blood-air barrier Cascade impactor 

FaSSIF Fasted state-simulating intestinal fluid 

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