Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Humans buccal

PENG Y s, PENG Y M, MCGEE D L and ALBERTS D s (1994) Carotenoids, tocopherols and retinoids in human buccal mucosal cells intra- and inter-individual variability and storage stability. J Clin Nutr 59(3) 636-43. [Pg.126]

The use of buccal cell cultures for assessing the permeability of the buccal mucosa has attracted recent attention (see Chap. 7 for a more extensive summary). In order to culture buccal epithelial cells, the cells must be harvested from an appropriate source and cultured under specific conditions using an appropriate growth medium, temperature, and humidity [46], Cell cultures have been successfully grown from hamster cheek pouch. These cultured cells, however, did not differentiate to form a complete keratinized surface as seen in the normal hamster cheek pouch, and they consequently displayed a greater permeability to compounds when compared with keratinized hamster cheek pouch mucosa [134], Therefore, the cultured hamster cheek cells more closely mimicked the human buccal mucosa due to their lack of keratinization, and so this may be an appropriate model for predicting permeability through the human buccal mucosa. [Pg.102]

Recently, a cell culture derived from biopsies of healthy human buccal mucosa has been developed with remarkably similar morphology, membranecoating granule structure and appearance, and lipid composition to intact buccal tissue [102], The barrier nature of this cell culture model is similar to intact buccal mucosa, and so this cell culture may be an alternative model to the... [Pg.102]

Adrian CL, Olin HB, Dalhoff K, Jacobsen J (2006) In vivo human buccal permeability of nicotine. Int J Pharm 311 196-202... [Pg.103]

Barsuhn CL, Olanoff LS, Gleason DD, Adkins EL, Ho NFH (1988) Human buccal absorption of flurbiprofen. Clin Pharmacol Ther 44 225-231... [Pg.103]

Evered DF, Mallett C (1983) Thiamine absorption across human buccal mucosa in vivo. Life Sci 32 1355-1358... [Pg.104]

Jacobsen J, Pedersen M, Rassing MR (1996) TR146 cells as a model for human buccal epithelium II. Optimisation and use of a cellular sensitivity MTS/PMS assay. Int J Pharm 141 217-225... [Pg.105]

Jacobsen J, Brpndum-Nielsen K, Christensen ME, Olin H-BD, Tommerup N, Rassing MR (1999) Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability. Eur J Oral Sci 107 138-146... [Pg.105]

Manning AS, Evered DF (1976) The absorption of sugars from the human buccal cavity. Clin Sci Mol Med 51 127-132... [Pg.107]

Nielsen HM, Rassing MR (1999a) TR146 cells grown on filters as a model of human buccal epithelium III. Permeability enhancement by different pH values, different osmolality values, and bile salts. Int J Pharm 185 215-225... [Pg.107]

Rathbone MJ (1991a) Human buccal absorption. I. A method for estimating the transfer kinetics of drugs across the human buccal membrane. Int J Pharm 69 103-108... [Pg.108]

Rathbone MJ (1991b) Human buccal absorption. II. A comparative study of the buccal absorption of some parahydroxybenzoic acid derivatives using the buccal absorption test and a buccal perfusion cell. Int J Pharm 74 189-194... [Pg.108]

Sadoogh-Abasian F, Evered DF (1979) Absorption of vitamin C from the human buccal cavity. Br J Nutr 42 15-20... [Pg.108]

Figure 7.2 presents permeation across freshly isolated porcine buccal mucosa of caffeine and atenolol. Caffeine and atenolol are compounds with complete and poor human buccal absorption in vivo, respectively [10, 29],... [Pg.169]

As noted earlier, the choice of species for experimentation is critical due to anatomical differences and it may also reflect species, as well as individual, differences in the expression/activity of transporter and metabolic proteins [43, 44], Since the fraction absorbed across buccal mucosa in vivo is not established for many compounds in different species including humans, the potential existence of a correlation between in vitro permeability coefficients in freshly isolated pig, dog, monkey, and human buccal mucosa was investigated (Figure 7.3). The correlation coefficient obtained for porcine and canine tissue was poor (0.65 and 0.67, respectively, at the 95% confidence level). Results for relatively high permeability compounds in porcine tissue resemble those previously reported where permeability coefficients were by an order of magnitude... [Pg.171]

Papp Across Fresh Human Buccal Mucosa... [Pg.171]

Figure 7.3 Correlation analysis for Fapp values across freshiy isolated animal buccal mucosa and freshly isolated human buccal mucosa of Lucifer yellow, enalaprilat, atenolol, caffeine, sumatriptan, and fentanyl. Results from internal study by Absorption Systems Company. Figure 7.3 Correlation analysis for Fapp values across freshiy isolated animal buccal mucosa and freshly isolated human buccal mucosa of Lucifer yellow, enalaprilat, atenolol, caffeine, sumatriptan, and fentanyl. Results from internal study by Absorption Systems Company.
Corresponding Papp value for atenolol and caffeine across freshly isolated human buccal mucosa mounted in Franz-type cell is 1.16 (0.25) and 14.5 (1.6), respectively. [Pg.173]

Figure 7.5 Mucosal-to-submucosal (m-s), Tapp values across human buccal culture of midazolam (CYP3A4 substrate), bufuralol (CYP2D6 substrate), tolbutamide (CYP2C9 substrate), and the nonmetabolized, high-permeability control compound caffeine (average SEM, N = 1 — 3 replicates). (Asterisk) in the presence of CYP inhibitors (CYP3A4-ketoconazole CYP2D6-quinidine CYP2C9-suphaphenazole). In all treatments integrity of the culture was verified by permeation of Lucifer yellow (< 2.0 x 10-6 cm/s). Results from internal study by Absorption Systems Company. Figure 7.5 Mucosal-to-submucosal (m-s), Tapp values across human buccal culture of midazolam (CYP3A4 substrate), bufuralol (CYP2D6 substrate), tolbutamide (CYP2C9 substrate), and the nonmetabolized, high-permeability control compound caffeine (average SEM, N = 1 — 3 replicates). (Asterisk) in the presence of CYP inhibitors (CYP3A4-ketoconazole CYP2D6-quinidine CYP2C9-suphaphenazole). In all treatments integrity of the culture was verified by permeation of Lucifer yellow (< 2.0 x 10-6 cm/s). Results from internal study by Absorption Systems Company.
Figure 7.6 Cumulative receiver concentrations of fentanyl, caffeine, and atenol vs time across cultured human buccal tissue (average SD, N = 3). Results from internal study by Absorption Systems Company. Figure 7.6 Cumulative receiver concentrations of fentanyl, caffeine, and atenol vs time across cultured human buccal tissue (average SD, N = 3). Results from internal study by Absorption Systems Company.
Obradovic T, Huynh T, Shingaki T, Strab B, Peck B, and Hidalgo JI (2005) Permeation across porcine buccal mucosa is correlated with absorption across human buccal mucosa. American Association Pharm. Sci. Abs. W4101. [Pg.179]

Agarwal V, Habib W, and Moe D (2005) Effervescent mediated transmucosal enhancement of fentanyl permeability Comparison across ex vivo porcine buccal mucosa and in vitro cultured human buccal epithelium test. American Association Pharm. Sci. Abs. T2126. [Pg.179]

Vondracek M, Xi Z, Larson P, Baker V, Mace K, Pfeifer A, Tjalve H, Donato MT, Gomez-Lechon MJ, and Grafstrom C (2001) Cytochrome P450 expression and related metabolism in human buccal mucosa. Carcinogenesis 22 481-488. [Pg.180]

Audus KL, Wiliams A, and Tavakoli-Saberi MR (1991) A comparison of aminopeptidases from excised human buccal epithelium and primary cultures of hamster pouch buccal epithelium. J. Pharm Pharmacol. 43 363-365... [Pg.180]

See other pages where Humans buccal is mentioned: [Pg.97]    [Pg.97]    [Pg.98]    [Pg.102]    [Pg.110]    [Pg.167]    [Pg.167]    [Pg.168]    [Pg.172]    [Pg.172]    [Pg.173]    [Pg.173]    [Pg.174]    [Pg.175]    [Pg.200]    [Pg.430]   
See also in sourсe #XX -- [ Pg.371 ]



SEARCH



Buccal

© 2024 chempedia.info