Epidermal growth factor cells

Boonstra, J., Rijken, P., Humbel, B., Cremers, F., Verkleij, A., and van Bergen en Henegouwen, P. 1995. The epidermal growth factor. Cell Biology International 19(5), 413-430. 

Clemente, R., Jones, D.R., Ochoa, P., Romero, G., Mato, J.M., and Varela-Nieto, 1. Role of glycosyl-phosphatidylinositol hydrolysis as a mitogenic signal for epidermal growth factor. Cell Signal,... 

Carpenter G (1984) Properties of the receptor for epidermal growth factor. Cell 37 357-358... 

Whereas epidermal growth factor (EGF) enhances the radiosensitivity of human squamous ceU carcinoma cells in vitro (197), addition of EGF to hormone-deprived MCE-7 breast cancer cells prior to irradiation results ia iacreased radioresistance (198). An anti-EGE-receptor monoclonal antibody blocks the abiUty of EGE to enhance growth and radioresistance. Tumor cells, the growth of which is stimulated by EGE, appear to be protected those where growth is iohibited are sensitized (198). 

These interactions involve adhesion proteins called selectins, which are found both on the rolling leukocytes and on the endothelial cells of the vascular walls. Selectins have a characteristic domain structure, consisting of an N-terminal extracellular lectin domain, a single epidermal growth factor (EGR) domain, a series of two to nine short consensus repeat (SCR) domains, a single transmembrane segment, and a short cytoplasmic domain. Lectin domains, first characterized in plants, bind carbohydrates... 

The epidermal growth factor receptor 2 (HER-2) is a protein found on the surface of cells. Heterodimerization of HER-2 activates the enzyme tyrosine kinase, triggering reactions that cause the cells to grow and multiply. HER-2 is found at abnormally high levels on the surface of many types of cancer cells, which may divide excessively. Antibodies targeting HER-2 (e.g., trastuzumab) are used as antineoplastic agents. 

Waters KM, Shankaran H, Wiley HS, Resat H, Thrall BD. Integration of microarray and proteomics data for biological pathway analysis and network modeling of epidermal growth factor signaling in human mammary epithelial cells. Keystone Symposia, 2005. 

PETERSON G and BARNES s (1993) Genistein and hiochanin A inhibit the growth of hiunan prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate. 22 (4) 335-45. 

Additional genes and protein receptors are believed to be important in colorectal tumorigenesis. Cyclooxygenase 2 (COX-2), which is induced in colorectal cancer cells, influences apoptosis and other cellular functions in colon cells, and overexpression of the epidermal growth factor receptor (EGFR), a transmembrane glycoprotein involved... 

Ahn, N. G., Weiel, J. E., Chan, C. P., and Krebs, E. G. (1990). Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. J. Biol. Chem. 265 11487-11494. 

Hidalgo, I. J. Kato, A. Borchardt, R. T., Binding of epidermal growth factor by human colon carcinoma cell (Caco-2) monolayers, Biochem. Biophys. Res. Commun. 160, 317-324 (1989). 

Meisner H, Daga A, Buxton J et al 1997 Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol 17 2217-... 

A device designed to determine the transport of an epidermal growth factor from a Pluronic gel, a Carbopol gel, and a vanishing cream base was shown capable of demonstrating formulation-dependent release kinetics [22], This device consists of a release cell which has a membrane to minimize release due to mechanical breakdown and is placed in a stirred and temperature-controlled receptor fluid. 

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