Enzymes mouse models

The original humanized mice bear the expression hPXR exclusively in the liver [10]. As both drug-metabolizing enzymes and xenobiotic receptors are also highly expressed in the intestinal tracts, it is conceivable that mouse models with the humanized receptors expressed in both the liver and the intestine would represent a... 

Coenzyme QIO (21) is one of the essential enzymes in the mitochondrial electron transport chain, participating in the aerobic respiration cycle. The role of Co-QlO as a cardioprotective substance and an antioxidant are well studied. Recently, it was found that Co-QlO is also capable of attenuating the intracellular deposition of Ap in transgenic AD mouse models. Additionally, the same group reported that Co-QlO administration also led to reduction of preexisting plaque burden in the same model. Such properties are suggestive of a potential therapeutic role for Co-QlO in AD. 

Representatives of another important class of plant-derived semisynthetic compounds are the camptothecin (27) derivatives, irinotecan (28) and topotecan (29). Camptothecin (27) was originally discovered as an antileukemic agent in a mouse model when isolated from Camptotheca acuminata Decne. Compounds (28) and (29) are both employed in cancer chemotherapy. These substances are important mechanistically because of their activity against the enzyme, topoisomerase I. These compounds were designed to address efficacy and toxicity concerns with the parent compound, camptothecin, and its sodium salt. ... 

Kidney Renal RAS Mouse model MALDI-TOF/ TOF-MS Molecular imaging of renal RAS Localization of AngW and enzymes activity in kidney regions (61)... 

Novel derivatives of benzofuran inhibitors have been synthesized to enhance inhibitory activity against C. albicans Nmt enzyme, with some exhibiting in vivo antifungal activity in mouse models of C. albicans infection (Masubuchi et al., 2001, 2003 Kawasaki et al., 2003). 

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