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Xenobiotic receptor

The implications of PXR-mediated gene regulation for drug metabolism and drug interadion have been recognized since the initial cloning of this xenobiotic receptor. [Pg.299]

The original humanized mice bear the expression hPXR exclusively in the liver [10]. As both drug-metabolizing enzymes and xenobiotic receptors are also highly expressed in the intestinal tracts, it is conceivable that mouse models with the humanized receptors expressed in both the liver and the intestine would represent a... [Pg.306]

Kliewer, S.A., Lehmann, J.M., Milburn, M.V. and Willson, T.M. (1999) The PPARs and PXRs nuclear xenobiotic receptors that define novel hormone signaling pathways. Recent Progress in Hormone Research, 54, 345-367. [Pg.314]

X receptor a promiscuous xenobiotic receptor that has diverged during evolution. Molecular Endocrinology, 14, 27-39. [Pg.335]

H.E. (2004) The nuclear xenobiotic receptor CAR structural determinants of constitutive activation and heterodimerization. Molecules and Cells, 16, 893-905. [Pg.336]

Watkins, R.E. et al. (2001) The human nuclear xenobiotic receptor PXR structural determinants of directed promiscuity. Science, 292 (5525), 2329-2333. [Pg.74]

Gonzalez, F. J. and Yu, A. M. (2006) Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol 46, 41-64. [Pg.54]

Zhou C, Assem M, Tay JC, et al. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest 2006 116(6) 1703-1712. [Pg.504]

Zhou C, Tabb MM, Sadatrafiei A, et al. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metab Dispos 2004 32(10) 1075-1082. [Pg.504]

SXR Steroid end xenobiotics receptor (human] CAR Constitutive active (androstane) receptor other UGT substrates... [Pg.241]

Klaassen, C.D., Slitt, A.L. (2005). Regulation of hepatic transporters by xenobiotic receptors. Curr. Drug. Metab. 6 309-28. [Pg.559]

Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 2002 298 422-4. [Pg.268]

Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, et al. 2000. The pregnane X receptor a promiscuous xenobiotic receptor that has diverged during evolution. Mol. Endocrinol. 14 27-39... [Pg.333]

Takeshita A, Koibuchi N, Oka J, et al. Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. Eur J Endocrinol 2001 145 513-17. [Pg.376]

See other pages where Xenobiotic receptor is mentioned: [Pg.7]    [Pg.1388]    [Pg.470]    [Pg.236]    [Pg.293]    [Pg.295]    [Pg.299]    [Pg.302]    [Pg.302]    [Pg.308]    [Pg.308]    [Pg.309]    [Pg.310]    [Pg.313]    [Pg.314]    [Pg.315]    [Pg.315]    [Pg.323]    [Pg.335]    [Pg.31]    [Pg.242]    [Pg.7]    [Pg.244]    [Pg.245]    [Pg.1328]    [Pg.1328]    [Pg.323]    [Pg.71]    [Pg.72]   
See also in sourсe #XX -- [ Pg.470 ]

See also in sourсe #XX -- [ Pg.191 , Pg.205 ]

See also in sourсe #XX -- [ Pg.714 , Pg.716 ]



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Animal models, of xenobiotic nuclear receptors

Orphan nuclear receptors as xenobiotic receptor

Receptor-xenobiotic interactions

Steroid and xenobiotic receptor

Steroid xenobiotic receptor

Xenobiotic Receptor Cofactors and Coregulators

Xenobiotic-Sensing Nuclear Receptors in Cancer, Oxidative Stress and Pollution

Xenobiotics receptor interactions

Xenobiotics receptors

Xenobiotics receptors

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