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Enzymes hypersensitivity

IgE Mediates immediate hypersensitivity by causing release of mediators from mast cells and basophils upon exposure to antigen (allergen). Defends against worm infections by causing release of enzymes from eosinophils. Does not fix complement. Main host defense against helminthic infections. [Pg.594]

Solutions of different pectic substances were injected into healthy wheat plants, with or without the glycoproteogalactan elicitor, and the activities of the enzymes PAL and POD were determined. These enzymes are involved in the hypersensitive reaction of wheat against the rust fungus, and increased activities can be expected after elicitation, whereas suppressor active substances will cause a reduction of the elicitor-induced enzyme activities. [Pg.690]

Mineral dust-induced ROMs contributes to pulmonary fibrosis, malignancy, hypersensitivity and emphysema (Doelman etctl., 1990 Kamp etui., 1992). The involvement of ROMs in pulmonary fibrotic reactions is indicated by the participation of PMN oxidants in the autoactivation of latent coUagenase (Weiss et al., 1985). Prolyl hydroxylase, a key enzyme in collagen fibril formation, has been shown to be dependent on the reaction of superoxide with prolyl residues (Myllyla et al., 1979). [Pg.250]

Mutation of the Target Enzyme Should Lead to Resistance or Hypersensitivity to Inhibitors... [Pg.138]

The other major arachidonic acid (AA) converting enzyme is an integral binding protein, 5-lipoxygenase, which is responsible for the initial transformation in a cascade of events towards the biosynthesis of leukotrienes. Leukotrienes are major mediators of numerous biological processes, including chemotaxis, and are implicated in hypersensitivity disorders like asthma. It was discovered in the early 1990s that another protein is necessary for the cellular synthesis of... [Pg.198]

Riley, R. et al., Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognize rodent C YP3 A proteins and a similarly regulated human P450 enzyme(s), Biochem. Biophys. Res. Commun., 191, 32, 1993. [Pg.466]

A rare but serious event that can result from irreversible CYP inhibition is the development of a hypersensitivity reaction. The bioactivation of a drug and the formation of a covalent adduct between the activated substrate and the enzyme can lead to hapten formation and eventually to an idiosyncratic autoimmune response (usually in the form of autoimmune hepatitis) [14]. The hapten formation is the first key step toward the autoimmune response. The CYP macromolecule is made immunogenic ( foreign ) by the covalent binding of the electrophilic metabolites, and the immune reaction follows with the production of autoantibodies against the target molecule (not necessarily alkylated). [Pg.269]

Soluble polymer conjugates have been introduced into clinical practice in the last decade [90,94], Several PEG conjugates have been evaluated clinically [145] for cancer therapy including a PEG conjugate of asparaginase in the treatment of ALL in patients hypersensitive to the native enzyme [146], and a PEG conjugate of IL-2 [147],... [Pg.225]

Rifampin. Source, antibacterial activity, and routes of administration are described on p. 274. Albeit mostly well tolerated, this drug may cause several adverse effects including hepatic damage, hypersensitivity with flu-like symptoms, disconcerting but harmless red/orange discoloration of body fluids, and enzyme induction (failure of oral Liillmann, Color Atlas of Pharmacology... [Pg.280]

In a recent study (54), we showed increased activities of two enzymes of the general phenylpropanoid pathway, PAL and 4-coumarate CoA lig-ase, as well as one enzyme of the specific pathway of lignin biosynthesis, cinnamy 1-alcohol dehydrogenase (CAD), in resistant plants at the time of the hypersensitive host cell death. On the other hand, decreased activities were observed at the same time with susceptible host plants (54). Furthermore, we showed that the well known increase in peroxidase activities, which is strong in resistant and only weak in susceptible plants (55-58), is at least partly due to the increased activity of the lignin biosynthetic pathway (54,59). [Pg.373]

Recently, Kogel et al. (98) showed that the injection of galactosebinding lectins or the enzyme galactose oxidase into resistant wheat leaves prevented the hypersensitive cell death of penetrated host cells and concomitantly led to increased fungal growth, suggesting a causal relationship between hypersensitive cell death and resistance. [Pg.374]

Laronidase (Aldurazyme) is recombinant-L-idu-ronidase. In mucopolysaccharidosis I (Hurler syndrome) there is a deficiency of the lysosomal enzyme a -L-iduronidase. Laronidase is employed for the non-neurological manifestations of Hurler syndrome. After intravenous infusion laronidase is eliminated with a half-life of 1.5-3.6 hours. Infusion related side effects are seen frequently. Hypersensitivity reactions may occur. [Pg.486]

Mild to moderate side effects, including nausea, vomiting, abdominal pain, diarrhea, anorexia, and headache, occur in up to 33% of patients taking this drug. Skin rash and discoloration, fever, reversible male infertility, and liver enzyme elevation occur less frequently. Rare hematological abnormalities, such as agranulocytosis, aplastic anemia, hemolytic anemia, neutropenia, or other blood dyscrasias, can be fatal. Hypersensitivity reactions occur rarely. [Pg.433]


See other pages where Enzymes hypersensitivity is mentioned: [Pg.84]    [Pg.84]    [Pg.1004]    [Pg.97]    [Pg.191]    [Pg.474]    [Pg.611]    [Pg.170]    [Pg.191]    [Pg.193]    [Pg.690]    [Pg.105]    [Pg.31]    [Pg.209]    [Pg.62]    [Pg.507]    [Pg.83]    [Pg.678]    [Pg.207]    [Pg.84]    [Pg.492]    [Pg.112]    [Pg.554]    [Pg.555]    [Pg.319]    [Pg.367]    [Pg.12]    [Pg.122]    [Pg.207]    [Pg.1686]    [Pg.1932]    [Pg.105]    [Pg.376]    [Pg.356]    [Pg.319]    [Pg.374]    [Pg.409]    [Pg.486]   
See also in sourсe #XX -- [ Pg.389 ]




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