Fibrotic Pulmonary Reactions

Extrinsic alveolitis (acute onset infiltrative) Pituitary snuff 

Eosinophilic pneumonitis Methotrexate p-Aminosalicylic acid Aurothioglucose Carbamazepine Chlorpropamide Cromolyn 

SLE-like or other less clear-cut autoimmune reactions p-Aminosalicylic acid Phenylbutazone 

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Mineral dust-induced ROMs contributes to pulmonary fibrosis, malignancy, hypersensitivity and emphysema (Doelman etctl., 1990 Kamp etui., 1992). The involvement of ROMs in pulmonary fibrotic reactions is indicated by the participation of PMN oxidants in the autoactivation of latent coUagenase (Weiss et al., 1985). Prolyl hydroxylase, a key enzyme in collagen fibril formation, has been shown to be dependent on the reaction of superoxide with prolyl residues (Myllyla et al., 1979). 

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