Enzymatic membrane bioreactor

The hydrolysis of caroteno-proteins for the production of astaxanthin using protease was developed in an enzymatic membrane bioreactor [19], in which the concentration of the protein fraction by ultrafiltration and the separation of the pigments in the permeate were simultaneously carried out. 

Lopez C, Moreira MT, Feijoo G et al (2004) Dye decolorization by manganese peroxidase in an enzymatic membrane bioreactor. Biotechnol Prog 20 74-81... 

Prazeres DMF, Cabral JMS (1994) Enzymatic membrane bioreactors and their applications. Enzyme Microb Technol 16 738-750... 

The modelling of enzymatic membrane reactors follows, in general, the same approach as described previously. In enzymatic membrane reactors the catalyst is a macromolecule (enzyme). It can be found either in a free form in the reactor or supported on the membrane surface, or inside the membrane porous structure by grafting it or in the form of a gel obtained by ultrafiltration. As in the case of the whole-cell membrane bioreactors discussed above, the proper calculation of the mass transfer characteristics is of great importance for the modelling of this type of reactor. One of the earliest models of enzymatic membrane bioreactors is by Salmon and Robertson [5.108]. These authors modelled an enzymatic membrane bioreactor, which was made of four coaxial compartments the enzyme is confined within one of the compartments, and one of the substrates is fed in a gaseous form. 

Xia, M. and Ying,T. J. 2011. Progress in enzymatic membrane bioreactor A review of research methodology and reaction characteristic. Advanced Materials Research, 236-238,2471-2476. 

In recent years, membrane bioreactors, bioreactors combined with membrane separation unit have established themselves as an alternative configuration for traditional bioreactors. The important advantages offered by membrane bioreactors are the several different types of membrane modules, membrane structures, materials commercially available. Membrane bioreactors seem particularly suited to carry out complex enzymatic/microbial reactions and/or to separate, in situ, the product in order to increase the reaction efficiency. The membrane bioreactor is a new generation of the biochemical/chemical reactors that offer a wide variety of applications for producing new chemical compounds, for treatment of wastewater, and so on. 

A very interesting field in membrane bioreactors is the production of cyclodextrins or oligosaccharides. In general, they have applications in food pharmaceutical, cosmetic agricultural, and plastics industries as emulsifiers, antioxidant, and stabilizing agents. In the food industry cyclodextrins are employed for the preparation of cholesterol-free products. The use of enzymatic membrane reactors to produce... 

Prazeres DMF, Cabral JMS (2001) Enzymatic membrane reactors. In Cabral JMS, Mota M, Tramper J (eds) Multiphase bioreactor design. Taylor Francis, London... 

Membrane bioreactor Asymmetric poly-sulfone membrane Diffusion of carbohydrates in liquid-filled pores Enzymatic hydrolysis of lactose Whole cells of Sutfolobus solfataricus entrapped in the tube wall 65... 

Slominska L, Szostek A, and Grzeskowiak A. Studies on enzymatic continuous production of cyclodextrins in an ultrafiltration membrane bioreactor. Carbohydr Polym, 2002 50(4) 423 28. 

Steady state models of membrane bioreactors utilizing a multi-enzyme system, which in addition to the main reaction promotes the simultaneous regeneration of the co-factor (for further discussion see Chapter 4) have been developed by different groups in Japan [5.109, 5.110]. Several of these studies have also considered the effect of backmixing [5.111, 5.112]. A model of an enzymatic hollow fiber membrane bioreactor with a single enzyme, which utilizes two different substrates (reaction 5.42) has been developed recently by Salzman et al [5.113]. 

Chapter 3 is devoted to the topic of pervaporation membrane reactors. These are unique systems in that they use a liquid feed and a vacuum on the permeate side they also mostly utilize polymeric membranes. Chapter 4 presents a survey of membrane bioreactor processes these couple a biological reactor with a membrane process. Reactions studied in such systems include the broad class of fermentation-type or enzymatic processes, widely used in the biotechnology industry for the production of amino acids, antibiotics, and other fine chemicals. Similar membrane bioreactor systems are also fin-... 

Xin JY, Li SB, Xu Y et al. (2001) Dynamic enzymatic resolution of naproxen methyl ester in a membrane bioreactor. J Chem Technol Biotechnol 76(6) 579-585... 

Kim, TJ, YD Lee and HS Kim (1993). Enzymatic production of cyclodextrins from milled corn starch in an ultrafiltration membrane bioreactor. Biotechnology and Bioengineering, 41, 88-94. 

Gan Q, Allen SJ, Taylor G. (2005). Analysis of process integration and intensification of enzymatic cellulose hydrolysis in a membrane bioreactor. J Chem Techrwl Biotechnol, 80(6), 688-698. 

Calabro V, Curcio S, De Paola M G, lorio G (2009b), Optimization of membrane bioreactor performance during enzymatic oxidation of waste bio-polyphenols . 

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