Enoxaparin Aspirin

Either UFH or LMWH should be administered to patients with NSTE ACS. Therapy should be continued for up to 48 hours or until the end of the angiography or PCI procedure. In patients initiating warfarin therapy, UFH or LMWHs should be continued until the International Normalized Ratio (INR) with warfarin is in the therapeutic range for 2 consecutive days. The addition of UFH to aspirin reduces the rate of death or MI in patients with NSTE ACS.47 Enoxaparin was mentioned as preferred over UFH in the 2002 ACC/AHA clinical practice guidelines, as two large clinical trials found a reduction in the combined endpoint of death, MI, or need for PCI in patients... 

Oral combination product (Aggrenox) 200 mg extended-release dipyridamole plus 25 mg aspirin Enoxaparin (low-molecular-weight heparin, Lovenox)... 

Blazing MA, de Lemos JA, White HD, et al., for the A to Z Investigators, Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin A randomized controlled trial. JAMA 2004 292 55-64,... 

Cohen M, Theroux P Borzak S, et al. Randomized double-blind safety study of enoxaparin versus unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes treated with tirofiban and aspirin the ACUTE II study, The antithrombotic combination using tirofiban and enoxaparin, Am Heart J 2002 144 470-477. 

Ross AM, Molhoek B Lundergan C, et al. Randomized comparison of enoxaparin, a low molecular weight heparin, with unfractionated heparin adjunctive to tissue plasminogen activator thrombolysis and aspirin second trial of Heparin and Aspirin Reperfusion Therapy (HART II). Circulation 2001 104 648-652. 

Clinically important, potentially hazardous interactions with aspirin, carbamazepine, clarithromycin, enoxaparin, HIV protease inhibitors, itraconazole, ketoconazole, phenobarbital, phenytoin, posaconazole, ritonavir, St John s wort, voriconazole... 

Over the next 2 days, the patient s symptoms resolved completely. To prevent a recurrence of this disease, the patient is most likely to be treated indefinitely with (A) Aminocaproic acid Aspirin Enoxaparin Urokinase Warfarin... 

Unfractionated heparin was weight adjusted. The ahciximab dose was the same regimen used in GUSTO V. Enoxaparin was given as an iv bolus of 30 mg, followed immediately by the first sc dose of 1 mg/kg, which was continued every 12 hours until mechanical revascularization, hospital discharge, or 7 days. All patients received oral aspirin. 

Serious retroperitoneal bleeding occurred in a patient with aeute eoronary syndrome reeeiving enoxaparin, elopidogrel and aspirin. ... 

Macias-Robles MD, Peliz MG, Gonzalez-Ordonez AJ. Prophylaxis with enoxaparin can produce a giant abdominal wall haematoma when associated with low doses of aspirin among elderly patients suffering cough attacks. Blood Coagul Fibrinolysis (2005) 16, 217-19. 

In a clinical study, 30 patients with unstable coronary disease treated pre-operatively with enoxaparin needed more heparin to maintain an activated clotting time above 480 seconds during surgery than 31 stable control patients not treated with enoxaparin. In addition, the enoxaparin recipients had higher heparin levels and lower antithrombin values compared with control patients. All patients were taking low-dose aspirin until the day before surgery, and received tranexamic acid as a bolus dose before cardiopulmonary bypass. ... 

The use of enoxaparin, ketorolac, and aspirin were considered to be contributing factors in a case of spinal haematoma occurring after lumbar puncture, which resulted in paraplegia. Another case has also been briefly described. In an analysis of reports from the FDA in the US, 16 of 43 patients who developed spinal or epidural haematoma after receiving enoxaparin had received concurrent drugs known to prolong bleeding, such as ketorolac or other NSAIDs. ... 

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