Emetic drugs

Mendelson s syndrome Cytoprotectants Mucosal protective drugs Prokinetic and anti-spasmodic drugs Laxatives Anti-diarrhoeals Nausea and vomiting Pharmacology of anti-emetic drugs Other substances Non-pharmalogical therapy INTRODUCTION... 

Metoclopramide and domperidone are discussed below in the section on anti-emetic drugs. 

Table 11.2 Receptor site affinity of anti-emetic drugs (modified from Peroutka and Snyder 1982 Hamik and Peroutka 1989)...

Chiorphenamine is effective in reducing pruritus from opioid drugs and may have synergistic activity with other anti-emetic drugs, although it is not primarily used as an anti-emetic. 

FIGURE 44.3 Sites of action of emetic drugs as employed clinically. 

Ackermann, B. L. Gillespie, T. A. Regg, B. T. Austin, K. E Coutant, J. E. 1996b. Application of packed capillary liquid chromatography/mass spectrometry with electrospray ionization to the study of the human biotransformation of the anti-emetic drug dolasetron. /. Mass Spectrom., 37,681-689. 

The nitro compound below was needed for the synthesis of an anti-emetic drug. It was proposed to make it by nitration of the hydrocarbon shown. How successful do you think this would be ... 

No. 5. Thus the a Hon of vomiting ceafes and is renewed by intervals, although the emetic drug is thrown up with the firlt eiFort. A tenefmus continues by intervals fome time after the cxclufion of acrid excrement 5 and the pulfations of the heart of a viper are faid to continue fome time after it is cleared from its blood. 

Indian tobacco (Lobelia inflata), also known as pukeweed , has been used for centuries by the Penobscots people in the Northeastern United States and the Canadian Maritimes, as an entheogenic and emetic drug, before Samuel Thompson (1769-1843), an herbalist from New Hampshire, claimed it as a valuable remedy. The roots were used for the treatment of sexually transmitted diseases, e.g. syphilis, and skin diseases were medicated with poultices from smashed leaves. By parenteral application, Indian tobacco is effective against oedema and asthma. Thus, Lobelia inflata was found since 1820 in many pharmacopoeias. 

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