Effect Relationship A

There may be several reasons for this pattern to be observed. One obvious reason is distribution, i.e. the drug needs time to reach its site of action, and the time lag between the measured drug concentration in plasma and the drug effect is due to distributional delay. In order to describe such a plasma concentration-effect relationship, a PK-PD model that allows for drug distribution to the site of action, e.g. the effect compartment model may be used. 

Figure 5.8. Concentration-effect relationship. A representative curve demonstrating the effects observed with increasing drug concentration, typ-icaiiy measured in piasma and expressed as an average and varied among individuais. Drug concentrations are piotted on a iog scaie. Maximum effect is achieved when no additionai effect intensity can be obtained with increasing drug concentration. A simiiar reiationship can be expressed as a function of dose administered to subjects, in this case the piot is caiied dose-effect or dose-response curve.

Figu re 3.7. Theoretical model to illustrate the effect of biochemical cascades on dose-effect relationships. a A simple model cascade, containing an agonist (L), a receptor (R), a second messenger (M2), and an effector (E). b Equations derived from the assumptions in a. ECjq Ligand concentration required for the half-maximal effect. The effect will saturate at concentrations lower than those required for receptor saturation. The gap between K and ECjq depends on the number of receptors and other properties of the system, c Illustration of the equations stated inb. 

Fig. 5. Concentration-effect relationships. (A) The concentration-effect relation ship of DHA. The shift in I4 is given as a function of DHA concentration for sodium currents squares) and...

Considering the epidemiological evidence of the health effects of particulate matter, the main purpose of toxicological studies was to prove the plausibility of the statistical associations, to elicit the components of particulate matter responsible for the health effects and to analyze the mechanisms of action and the dose-effect relationship. A vast body of data has accumulated during the past 10 years (for an overview see, US-EPA 2004, 2008). 

A very important thermodynamic relationship is that giving the effect of surface curvature on the molar free energy of a substance. This is perhaps best understood in terms of the pressure drop AP across an interface, as given by Young and Laplace in Eq. II-7. From thermodynamics, the effect of a change in mechanical pressure at constant temperature on the molar h ee energy of a substance is... 

The applicability of the two-parameter equation and the constants devised by Brown to electrophilic aromatic substitutions was tested by plotting values of the partial rate factors for a reaction against the appropriate substituent constants. It was maintained that such comparisons yielded satisfactory linear correlations for the results of many electrophilic substitutions, the slopes of the correlations giving the values of the reaction constants. If the existence of linear free energy relationships in electrophilic aromatic substitutions were not in dispute, the above procedure would suffice, and the precision of the correlation would measure the usefulness of the p+cr+ equation. However, a point at issue was whether the effect of a substituent could be represented by a constant, or whether its nature depended on the specific reaction. To investigate the effect of a particular substituent in different reactions, the values for the various reactions of the logarithms of the partial rate factors for the substituent were plotted against the p+ values of the reactions. This procedure should show more readily whether the effect of a substituent depends on the reaction, in which case deviations from a hnear relationship would occur. It was concluded that any variation in substituent effects was random, and not a function of electron demand by the electrophile. ... 

Although isothiazole (pK = 1.90) is less basic than thiazole, its rale of quaternization by dinitrophenyl acetate in water at 52°C is approximately 2.5 times higher (447). This deviation from the Bronsted relationship (A log k - 0.ApK, with positive) is interpreted as a consequence of the or effect of the adjacent sulfur lone pair in isothiazole that is responsible for its higher nucleophilicity (448, 449). 

Materials for Electrooptic Modulation. The fundamental phenomenon of Pockel s effect is a phase change, A( ), of a light beam in response to a low frequency electric field of voltage, V. Relevant relationships for coUinear electrical and optical field propagation are as foUows (1 6) ... 

An especially interesting case of oxygen addition to quinonoid systems involves acidic treatment with acetic anhydride, which produces both addition and esterification (eq. 3). This Thiele-Winter acetoxylation has been used extensively for synthesis, stmcture proof, isolation, and purification (54). The kinetics and mechanism of acetoxylation have been described (55). Although the acetyhum ion is an electrophile, extensive studies of electronic effects show a definite relationship to nucleophilic addition chemistry (56). 

The physiological effect of a particular lens can be determined by measuring the increased thickness of the cornea after lens wear studies have shown the relationship between the DkjD of a lens and the subsequent swelling of the underlying cornea (20,21). 

The pK values are approximately additive and a linear relationship of the type pKT " -pK° + Y. pKm holds for the whole set (pK° is the pK. of pyrazole itself and is the effect of a substituent m at position n). Deviation from the additivity is found when two bulky substitu ts are in contiguous positions. Instead of discussing pK, values, the authors consider ApisTm which are mean values and thus more significant since they correspond to several pairs of compounds. 

Darcy s law has been used to derive an expression which reflects not only the effect of a change in elevation, but also provides a means for estimating changes in air rate resulting from changes in vacuum level and cake thickness (or cake weight per unit areaj. In order for this relationship to hold for changes in vacuum and cake thickness, it must be assumed that both cakes have the same specific resistance. 

Both contamination and pollution entail the perturbation of the natural state of the environment by anthropogenic activity. The two terms are distinguishable by the severity of the effect pollution induces the loss of potential resources. Additionally, a clear cause-effect relationship must be established for a substance to be classified as a pollutant towards a particular organism. 

In addition to freedom from bottoming out , most people prefer a seat which effectively provides a soft surface with a firm interior. One measure of the relationship between such surface softness and inner support is the sag factor or support factor. In one commonly used test this is obtained by dividing the force required to compress a foam by 65% of its height by the force needed to obtain 25% sample compression. This generally increases with density but is typically <2.5 for a conventional slabstock foam but >2.5 for a high-resilience foam. 

The term nucleophilicity refers to the effect of a Lewis base on the rate of a nucleophilic substitution reaction and may be contrasted with basicity, which is defined in terms of the position of an equilibrium reaction with a proton or some other acid. Nucleophilicity is used to describe trends in the kinetic aspects of substitution reactions. The relative nucleophilicity of a given species may be different toward various reactants, and it has not been possible to devise an absolute scale of nucleophilicity. We need to gain some impression of the structural features that govern nucleophilicity and to understand the relationship between nucleophilicity and basicity. ... 

Dose-response the relationship between the dose of a pollutant and its effect on a... 

KDC has a cause and effect relationship between as the primary cause leading to secondary failures. Besides its drastic operational effects on redundant systems, the numerical etlects that reduce sy.stem reliability are pronounced Equation 2.4-5 shows that the probability ut failing a redundant. system composed of n components is the component probability raised to the n-th power. If a common clement couples the subsystems. Equation 2.4-5 is not correct and the failure rate is the failure rate of the common element. KDC is very serious because the time from primary failure to secondary failures may be too short to mitigate. The PSA Procedures Guide (NUREG,/CR-2.3(X)) cl.issities this type as "Type 2."... 

A toxic reaction may take place during or soon after exposure, or it may only appear after a latency period. Chronic toxicity requires exposure of several years for a toxic effect to occur in humans. With respect to experimental animals, the animals are usually exposed for most or all of their life time to ascertain the occurrence of chronic toxicity. Acute toxic reactions that occur immediately are easy to associate with the exposure and the exposure-effect relationship can readily be demonstrated. The longer the time interval between exposure and effect, the more difficult it is to delineate the relationship between exposure and effect. 

A kinetic isotope effect that is a result of the breaking of the bond to the isotopic atom is called a primary kinetic isotope effect. Equation (6-88) is, therefore, a very simple and approximate relationship for the maximum primary kinetic isotope effect in a reaction in which only bond cleavage occurs. Table 6-5 shows the results obtained when typical vibrational frequencies are used in Eq. (6-88). Evidently the maximum isotope effect is predicted to be very substantial. 

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