Effect, carcinogenic teratogenic

In summary, preliminary results from two animal models (rabbit and mouse) indicate that poly(N-palmitoylhydroxyproline ester) elicits a very mild, local tissue response that compares favorably with the responses observed for established biomaterials such as medical grade stainless steel or poly(lactic acid)/poly(glycolic acid) implants. At this point, additional assays need to be performed to evaluate possible allergic responses, as well as systemic toxic effects, carcinogenic, teratogenic, or mutagenic activity, and adaptive responses. 

Toxicological information acute effects, LD50 data, chronic effects, carcinogenicity, teratogenicity, mutagenicity. 

In terms of toxicity, NIOSH recommends that endosulfan be recognized as a Group 1 Pesticide (NIOSH 1992). Pesticides in Group 1 pose a significant risk of adverse acute health effects at low concentrations or carcinogenic, teratogenic, neurotoxic, or reproductive effects (NIOSH 1992). 

Human toxicity Acute effects Carcinogenicity Genotoxicity/mutagenicity Developmental Teratogenicity/mutagenicity Neurotoxicity Endocrine disruption... 

TDL, the toxic do.se low, the smallest possible dose of the material causing poisonous effects, carcinogenicity, mutagenicity, or teratogenicity). 

Episodic pollution events can adequately be addressed by acute toxicity bioassays, however these are not sufficient to investigate the water quality for delayed toxicity effects of chemicals present. Chronic effects of pesticides can include carcinogenicity, teratogenicity, mutagenicity, neurotoxicity, and reproductive effects (endocrine disruption). 

Type D Delayed effects (e.g., carcinogenicity, teratogenicity) Low incidence... 

PASS Predicts 900 pharmacological effects, mechanisms of action, mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity... 

TDLo/Toxic Dose Low—The lowest dose introduced by any route other than inhalation over any period of time that produces any toxic effect in humans or that produces carcinogenic, teratogenic, mutagenic, or neoplastic effects in humans and animals. 

The problem is that nuclear wastes contain radioactive isotopes that release life-threatening ionizing radiation that may pose a threat to humans and the environment for hundreds, thousands, or even millions of years. This radiation can cause carcinogenic, teratogenic, and mutagenic effects in small amounts and can result in radiation sickness and death in larger amounts. 

DegraeVE, N. (1981). Carcinogenic, teratogenic and mutagenic effects of cadmiiun, Mutat. Res. 86,115. 

Chronic Effects Chronic effects generally occur as a result of long-term exposure, and are of long duration. The term is often used to cover only carcinogenicity, teratogenicity, and mutagenicity. These effects are serious concerns in the workplace, however there are many other chronic effects such as blood dyscrasia (e.g., anemia), chronic bronchitis, and liver atrophy. The reader may refer to 52 FR 31884. 

TOPKAT Automated Rule-Induction Systems Accelrys Ltd. www.accelrys.com/products/topkat/ mutagenicity, teratogenicity, membrane irritation, neurotoxicity, and other effects Carcinogenicity,... 

ToxScope Function Based Drug Design, V.N. Orekhovich Institute of Biochemical Chemistry LeadScope Inc. www.leadscope.com/products/txs.htm teratogenicity, embryotoxicity, and many other effects Carcinogenicity and many... 

Azamethiphos has not been found to be carcinogenic, teratogenic, or to result in reproductive toxicity in rodent studies. The no-observed-adverse-effect level established in a 52 week study with beagles fed azamethiphos was 2.7-2.9mgkg day in males and females, respectively. Azamethiphos did not cause delayed neuropathy in hens given two LD50 dosages 21 days apart. 

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