Edema drug induced

Open-angle glaucoma, secondary glaucoma, preoperatively to lower Intraocular pressure (IOP), edema due to CHF, drug-induced edema, centrencephalic epilepsy Glaucoma... 

Suggested Alternatives for Differential Diagnosis Drug induced noncardiac pulmonary edema, acute respiratory distress syndrome, pneumonic plague, tularemia, Q fever, and viral influenza. 

Drug-induced edema - Most effective if given every other day or for 2 days alternating with a day of rest. 

The side effects of mycophenolate mofetil include diarrhea, abdominal pain, constipation, nausea/vomiting, acne, dyspnea, cough, peripheral edema, increased risk of infections, drug-induced fever, dizziness, headaches, leukopenia and anemia. 

Ocular Effects. Drug-induced transient myopia has been reported with several sulfonamides. Acetazolamide, an imsubstituted heterocyclic sulfonamide, has also been associated with myopic shifts in refractive error. Shallowing of the anterior chamber is the only variable documented to change in eyes exhibiting this increase in myopia after sulfonamide therapy. Myopia probably results from ciliary body edema that produces a forward displacement of the lens-iris diaphragm. The myopia subsides on reduction or discontinuation of acetazolamide therapy (see Chapter 35). 

Diuretic agents can cause myopia. Transient myopia was associated with perimacular edema apparently caused from the use of 100 mg of hydrochlorothiazide. The drug induced approximately 3.00D of myopia, which resolved within 3 days. Carbonic anhydrase inhibitors are also known to cause myopia. A case of transient myopia associated with acetazolamide was reported, in which there was also narrowing of the anterior chamber angle. 

Figure 35-7 Mechanism of drug-induced myopia. (A) Image on retina in normal eye. (B) Drug-induced ciliary body edema causes relaxation of zonules, which in turn causes thickening of crystalline lens and myopic shift of refractive error.

The close temporal relation between the ingestion of hydrochlorothiazide and the onset of symptoms, together with rapid and fuU clinical recovery after withdrawal of therapy, suggested drug-induced pulmonary edema and possible anaphylactoid hypotension. 

A 59-year-old man who had been taking tranilast 600 mg/day for 15 weeks developed bladder irritability (4). Cystoscopy showed extensive mucosal edema, strongly suggestive of drug-induced cystitis. He stopped taking tranilast and the symptoms disappeared within 3 weeks. 

Egeberg studied a number of acute states and found that a rise of factor VIII was associated with the induction of nonspecific fever (E6, ElO), intravenous infusion of serum (E7), intramuscular injection of blood (E8) or intravenous infusion of hemolyzed blood (E2), drug-induced diuresis in a patient with cardiac edema (Ell), and surgical operations (El). In the very acute changes, factor VIII alone rose in concentration, but where the process occupied several days there were normally associated increases in fibrinogen and in factor V. Other clotting factors remained at their previous levels. These investigations were all made in persons with normal hemostasis. 

Collagen vascular disease Pneumoconiosis Drug-induced lung disease Pulmonary edema Infiltrative lung diseases Granulomatosis Tumor... 

The most common drug-induced noncardiogenic pulmonary edema is ... 

Hefi ier and Sahn, 1981). In the case of salicylate-induced edema, drug levels can be lowered with forced alkaline diuresis and then pulmonary edema clears quickly. 

I. Pharmacology. Pentobarbital is a short-acting barbiturate with anticonvulsant as well as sedative-hypnotic properties. It is used as a third-line drug in the treatment of status epilepticus. It may also reduce intracranial pressure in patients with cerebral edema by inducing vasoconstriction. After intravenous administration of a single dose, the onset of effect occurs within about 1 minute and lasts about 15 minutes. Pentobarbital demonstrates a biphasic elimination pattern the half-life of the initial phase is 4 hours, and the terminal phase half-life is 35-50 hours. Effects are prolonged after termination of a continuous infusion. 

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