Drug-induced pulmonary edema

Suggested Alternatives for Differential Diagnosis Drug induced noncardiac pulmonary edema, acute respiratory distress syndrome, pneumonic plague, tularemia, Q fever, and viral influenza. 

The close temporal relation between the ingestion of hydrochlorothiazide and the onset of symptoms, together with rapid and fuU clinical recovery after withdrawal of therapy, suggested drug-induced pulmonary edema and possible anaphylactoid hypotension. 

IL-2 has been used in the treatment of sohd tumors such as metastatic melanoma, metastatic renal cell carcinoma, and colorectal carcinoma. Interleukin-2 infusions are associated with significant dose-dependent toxicity characterized by fevers, malaise, nausea, vomiting, diarrhea, hepatic dysfunction, pulmonary edema, somnolence, confusion, dysrhythmias, myocardial infarction, hematopoietic suppression, and renal insufficiency [10]. IL-2 has a short serum half-life of 6-10 min and a clearance of 30-60 min after bolus intravenously infusion [11]. Resultant toxicity is generally transient and reversible. It is possible that IL-2 induced renal failure only occurs in the setting of profound hypotension, prior volume depletion, concurrent administration of potentially nephrotoxic drugs, or the presence of underlying renal disease. 

Huh D, Leslie DC, Matthews BD et al (2012) A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med 4(159) 159ral47... 

Collagen vascular disease Pneumoconiosis Drug-induced lung disease Pulmonary edema Infiltrative lung diseases Granulomatosis Tumor... 

The most common drug-induced noncardiogenic pulmonary edema is ... 

TABLE 29—4. Drugs That Induce Pulmonary Edema ... 

IL-2, a cytokine used alone or in combination with cytotoxic drugs, has been reported to induce pulmonary edema. Although other cytokines have been associated with pulmonary edema, the problem is most significant with IL-2. A weight gain of 2 kg has been reported after treatment with IL-2. ... 

Hefi ier and Sahn, 1981). In the case of salicylate-induced edema, drug levels can be lowered with forced alkaline diuresis and then pulmonary edema clears quickly. 

Nonsteroidal anti-inflammatory medications may occasionally induce pulmonary infiltrates and eosinophilia. Drug-induced lupus erythematosus and non-cardiogenic pulmonary edema have also been described. 

During the period of neutropenia, patients have a significant risk of developing non-infectious pulmonary complications such as pulmonary edema, engraftment syndrome, alveolar hemorrhage, and drug-induced lung injury. 

Glaucoma (decreases formation of aqueous humor i IOP), acute mountain sickness (— - pulmonary and cerebral edema), metabolic alkalosis (e.g., thiazide-induced), elimination of acidic drugs (e.g., ASA, uric acid). 

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