Easi-dose

Nicotine nasal sprays These are the most rapidly acting of all nicotine replacement therapies, offering fast relief for cravings and also easy dose adjustments which can be made by the patient. 

Diabetics have traditionally been forced to perform self-injection, so auto-injectors have been developed for use in this area and look like a modem felt-tip pen. Quantities of insulin can be pre-set by turning a knob on the pen which has features including an audible click, clear resistance prior to each dose and a visual indication on the scale thus helping to eliminate dosing errors. Quick and easy dosing is possible with such systems. Auto-injectors are marketed by a number of companies under the following tradenames Novopen , Novepen II, NovoLet , Optipen II and D-Pen . Pressurised needleless systems are also now available. 

Outstanding properties Dust-free, easy dosing... 

The development of easy-to-use assays for determining theophylline blood levels afforded a handle on maintenance of effective but nontoxic levels. The relatively good availabihty of such assays in the United States probably contributed to the historical preference for theophylline treatment by U.S. physicians. Careful titration of the dose must be done on a patient-by-patient basis because individual rates of metaboHsm vary widely. Most ( 85%) of an oral dose of theophylline is metabolized by Hver microsomal enzymes. As a result many dmgs, eg, cimetidine [51481-61-9], anticonvulsants, or conditions, eg, fever, cigarette smoking, Hver disease, which affect Hver function alter theophylline blood levels. 

Inhalation of other general anesthetics susceptible to abuse, such as ether and chloroform, appears to be limited to health professionals who have easy access to these compounds and who tend to use these dtugs in isolation. Recreational and social use of these substances has been somewhat limited by their high flammability and by frequent and intense undesirable adverse effects at moderate doses. It has been suggested that the abuse of ether or chloroform alone is a rare phenomenon (Delteil et al. 1974 Deniker et al. 1972), occurring usually in the context of dependence on othet substances, particularly alcohol (Krenz et al. 2003). 

No need for special dosing equipment Both automatic and manual control Efficient dispersion effect Flexibility in run length Easy to maintain and robust machine Wide application field... 

Given the unexpected occurrence of anaphylaxis, the rapidity with which symptoms evolve after exposure to the trigger, and the observation that delay in epinephrine injection is associated with fatality [15, 16], randomized controlled trials of epinephrine in anaphylaxis will not be easy to conduct however, it is time to consider the possibility of performing such trials. Future directions with regard to studies of the optimal dose and optimal route of administration of epinephrine in anaphylaxis that do not involve a placebo control will be outlined at the end of this review [17]. 

Some studies have evaluated the feasibility, safety, and efficacy of combined IV rt-PA at a dose of 0.6 mg/kg with lAT in patients presenting with acute strokes within 3 hours of symptom onset. This approach has the potential of combining the advantages of IV rt-PA (fast and easy to use) with the advantages of lAT (directed therapy, titrated dosing, mechanical aids to recanalization, and higher rates of recanalization), thus improving the speed and frequency of recanalization. 

Systemic adverse effects are dose-dependent and are rare at low to medium doses however, high-dose inhaled corticosteroids have been associated with adrenal suppression, decreased bone mineral density, skin thinning, and easy bruising.3,29 Growth suppression in children may occur even with low-dose inhaled corticosteroids however, suppression appears to occur primarily in the first year of treatment and may be due to delayed growth with the potential of future catch-up growth.30... 

The most widely-accepted dose response model at the present time is the multi-stage model, which has great flexibility in curve-fitting, and also has a strong physiological justification. Although it is difficult to implement, there are already computer codes in existence that estimate the model parameters (13). The two most widely-used models, until recently, were the one-hit model and the log-probit model. They are both easy to implement, and represent opposite extremes in terms of shape - the former represents the linear non-threshold assumption, whereas the latter has a steep threshold-like curvature. In numerous applications with different substances it has been found that these three... 

Production of ozone by irradiation or electric discharge in oxygen is readily revealed by the characteristic odor. The yield, though, is not easy to establish. In a closed system, it is very small in a flow system, it increases with the flow rate and decreases with the dose rate. These have been explained by taking the formation reaction as a three-body combination with O atom, O + 202— 03 + 02 (no chain), where the back reaction is indeed a chain process (Magee and Burton, 1951). In the mass spectrometer, 02+ is the main ion but the total yield of excited states is about the same as that of ionization (about 3.1), giving the following initial species ... 

Biosensors are the analytical systems, which contain sensitive biological elements and detectors. Plant cells as a possible biosensors have natural structure that determinates their high activity and stability. Criteria in the screening of the plant cells as biosensors for allelopathy should be as under (i) Reaction is fast based on the time of response, (ii) Reaction is sensitive to small doses of analysed compounds or their mixtures and (iii) Methods of detection viz., biochemical, histochemical, biophysical (in particular, spectral changes in absorbance or fluorescence) are easy in laboratory and in the field conditions. The search of biosensors in active plant species is suitable to determine the mechanisms of action of biologically active substances or external factors of the environment (Roshchina and Roshchina, 2003 Roshchina, 2004 2005 c)). 

Consumer relevant characteristics of tablets are easiness of dispensing and convenience in handling, i.e., no dosing and dispensing aids are needed. Other advantages include precise dosing and smaller packages compared to powder products, due to their concentration. 

The course of post-LSD pupillary changes, with respect to dosage schedule and intensity and duration of effects, is a valuable tool. Pupil size 3 hr after the initial dose responded to the second dose of LSD and was an obvious measure to track in acute tolerance studies in humans. Given the number of rat studies in which this would be useful to monitor, the problem lies in determining rat mydriasis (easy in other animals) while a computerized pupillometer (developed by Martin Adler at Temple University) was informally tried by us once with LSD, systematic studies have not been done. 

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