E3 ubiquitin ligase

WW domains (named after the one letter abbreviation for the amino acid tryptophan) are small regions of around 30 residues, which, like SH3 domains, bind to polyproline sequences. These sequences often contain the consensus sequence PPXY or PPLP. Examples of proteins that contain WW domains include Nedd4 E3 ubiquitin ligase (Fig. 1) and IQGAP1. 

Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, ChenZ, Inoue S, Jung JU (2007) TRIM25 RING-flnger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446 916-920... 

Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell 2003 5(5) 709-722. 

Mailer That is a question I have been wanting to address. The apoptosis response can be driven wholly by a maternal programme that doesn t require transcription. If it is p53-dependent, it would be a non-transcriptional effect of p53. We haven t been able to completely get rid of p53. The most direct approach we have tried is to inject the papilloma virus E6 protein into embryos. This is an E3 ubiquitin ligase that degrades p53. There is something like lOng of p53 in every oocyte, so we can only get rid of half of this. Thus we haven t been able to answer the question of whether this response is p53 dependent or not. 

CoscoY, L., D. J. Sanchez, and D. Ganem, a novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. / Cell Biol, 2001, 155(7), 1265-73. 

XiA, Y., et al.. Enhancement of BRCAl E3 ubiquitin ligase activity through direct interaction with the BARDl protein. / Biol Chem, 2003, 278(7), 5255-63. 

Jiang, J., et al., CHIP is a U-box-dependent E3 ubiquitin ligase identification of Hsc70 as a target for ubiquitylation. J Biol Chem, 2001, 276(46), 42938-44. 

Fang, D., et al., Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidy-linositol 3-kinase for ubiquitination... 

Demand, J., et al., Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/ proteasome coupling. Curr Biol, 2001, 11(20), 1569-77. 

Hagglund, R. and Roizman, B. Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-l-infected cell protein 0. Proc. Natl. Acad. Sci. USA 2002, 99, 7889-94. 

Noueeddine, M. a., et al., Drosophila Rocla encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Dev Cell,... 

Cyr, D. M., Hohfeld, J. and Patterson, C. Protein quality control U-box-containing E3 ubiquitin ligases join the fold. Trends Biochem Sd 2002, 27, 368-75. 

Coen, P. G., McDonald, E. R., 3rd, Herman, J. G., and El-Deiey, W. S. Tat-binding protein-1, a component of the 26 S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat Genet... 

Hirata T, Lipp JJ, Toh BH, Peters JM (2005) Histone H3 serine 10 phosphorylation by Aurora B causes HPl dissociation from heterochromatin. Nature 438 1176-1180 Horn PJ, Bastie JN, Peterson CL (2005) A Rikl-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation. Genes Dev 19 1705-1714... 

Parkin The Causative Gene of AR-JP Encoding an E3 Ubiquitin-Ligase... 

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