Response dynamic respiratory

Optimal flow ratios are also a characteristic of oxidative phosphorylation, and may provide additional information on the relationships between the respiratory response and energy demand stimulation by ADP. Most metabolic processes in living cells are dynamic systems, and the behavior of flows may better reflect complex system mechanisms than do the models dependent on end-point measurements. For example, the ratio of ADP/O describes the state of the end-point capacity of oxidative phosphorylation based on the input flow of ADP. 

Pulmonary dynamics, the dimension and geometry of the respiratory tract and the structure of the lungs, together with the solubility and chemical reactivity of the inhalants greatly influence the magnitude of penetration, retention, and absorption of inhaled gases, vapors (Dahl, 1990), and aerosols (Raabe, 1982 Phalen, 1984). The quantity of an inhalant effectively retained in the pulmonary system constitutes the inhaled dose that causes pharmacotoxic responses. 

Y. Gu, V. Bourke, J.G. Kim, A. Constantinescu, R.P. Mason, H. Liu, Dynamic response of breast tumor oxygenation to hyperoxic respiratory challenge monitored with three oxygen-sensitive parameters, Appl. Opt. 42 (2003) 1-8. 

With respect to whole cell biosensors utilising dissolved oxygen probes, Liang et al. reported a four-layer model to describe the signals from an oxygen probe used to transduce the respiratory activity of mouse leukaemia tumour cells [13]. This work was carried out with a view to using the biosensor to study the dynamic responses to various drugs. Finite difference methods were used to solve the material balances between the inner... 

Information on representative exposures must be linked to information about cases of occupational asthma, which should be as complete as possible. However, this is a new area for research and most exposure-response analyses so far have come from research which is likely to be seriously deficient the number of cases is underestimated or they are unrepresentative of cases in general or both. This is because most research has used prevalence measures (number of cases present/number of workers at risk) within dynamic population cross-sections (those working in a workplace at one point in time). This approach yields data rapidly but is at risk of survivor bias. Workers with respiratory symptoms related to their work are much more likely to leave their job than other workers and it is likely that this selective turnover operates most strongly in the most highly exposed jobs. 

Graham, J.W. A. et al. (2007) Glycolytic enzymes associate dynamically with mitochondria in response to respiratory demand and support substrate channeling. Plant Cell 19, 3723-3738... 

The dynamic response of the peripheral chemoreceptors to P Oj may be modeled in a similar fashion but the steady-state response is hyperbolic (Cunningham et al., 1986). Furthermore, hypoxia and hypercapnia have a multiplicative effect on carotid chemoreceptor discharge (Fitzgerald and Lahiri, 1986), although the effect of changes m pH is presumably additive (Cunningham et al., 1986). Prolonged hypoxia has a depressant effect on central respiratory neurons (Neubauer et al., 1990) which may offset the stimulatory effect of peripheral chemosensitivity. 

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