Respiratory response

Ammann HM. 1986. A new look at physiologic respiratory response to hydrogen sulfide poisoning. Journal of Hazardous Materials 13 369-374. 

There appears to be no question that the guinea pig is more sensitive to HQ than the rat or the mouse. Whether or not this greater sensitivity is meaningful in terms of human exposure is uncertain. Sublethal, respiratory responses of the guinea pig to the inhalation of HCI are claimed to be more comparable to those of humans,... 

Thurberg, F.P., W.D. Cable, M.A. Dawson, J.R. Maclnnes, and D.R. Wenzloff. 1975. Respiratory response of larval, juvenile, and adult surf clams, Spisula solidissima to silver. Pages 41-52 in J.J. Cech, Jr., D.W. Bridges and D.B. Horton (eds.). Respiration of Marine Organisms. TRIGOM Publ., South Portland, ME. 

Thurberg, F.P. and R.S. Collier. 1977. Respiratory response of dinners to silver. Mar. Pollut. Bull. 8 40-41. 

Gehrke, P.C. 1988. Acute cardio-respiratory responses of spangled perch, Leiopotherapon unicolor (Gunther 1859), to sublethal concentrations of zinc, temephos and 2,4-D. Austral. Jour. Mar. Freshwater Res. 39 767-774. 

Kaplan, H.L. 1987. Effects of irritant gases on avoidance/escape performance and respiratory response of the baboon. Toxicology 47 165-179. 

Burleigh-Flayer, H. and Y. Alarie. 1987. Concentration-dependent respiratory response of guinea pigs to paraquat aerosol. Arch. Toxicol. 59 391-396. 

The respiratory response to metabolic alkalosis is to increase PaC02 by hypoventilation. 

Some patients lose the ability to increase the rate or depth or respiration in response to persistent hypoxemia. This decreased ventilatory drive may be due to abnormal peripheral or central respiratory receptor responses. This relative hypoventilation leads to hypercapnia in this situation the central respiratory response to a chronically increased PaC02 can be blunted. Because these changes in Pa02 and PaC02 are subtle and progress over many years, the pH is usually near normal because the kidneys compensate by retaining bicarbonate. 

For example, Rinehart (1962) and Rinehart and Hatch (1964) showed that the CT product appears to be a valid way to express pulmonary irritation due to phosgene exposure in rats. This is based on the finding of equal degrees of respiratory response, as measured by reduction in pulmonary gas exchange... 

Karel, L. and Weston, R.E. 1947. The biological assay of inhaled substance by the dosimetric method The retained median lethal dose and the respiratory response in unanesthetized, normal goats exposed to different concentrations of phosgene. J. Ind. Hyg. Toxicol. 29 23— 28. 

Weston, R.E. and Karel, L. 1946. An application of the dosimetric method for biologically assaying inhaled substances The determination of the retained median lethal dose, percentage retention, and respiratory response in dogs exposed to different concentrations of phosgene. J. Pharmacol. Exptl. Ther. 88 195. 

Relevant examples of the use of classification techniques range from the simple to the complex. Schaper et al. (1985) developed and used a very simple classification of response methodology to identify those airborne chemicals which alter the normal respiratory response induced by C02. At the other end of the spectrum, Kowalski and Bender (1972) developed a more mathematically based system to classify chemical data (a methodology they termed pattern recognition). 

A close relation between the extent of byssinosis and the contamination of cotton by GNB has been demonstrated in several studies ( > j )- It has been shown that FEV. decrements in textile mills correlated best with the square root or the product of dust concentration and numbers of GNB in raw cotton ( ). It has also been demonstrated that the cotton bract contains an agent or agents capable of eliciting acute respiratory responses during human challenge tests (, 7.) ... 

Murphy, S. D., D. A. Klingshim, and C. E. Ulrich. Respiratory response of guinea pigs during acrolein inhalation and its modification by drugs. J. Pharmacol. Exp. Therap. 141 79-83, 1%3. 

If the breathing zone concentration reaches 0.5 ppm, the possibility of respiratory response is imminent. Depending on the... 

Amdur MO, et al Respiratory response of guinea pigs to low levels of sulfuric acid. Environ Res 5 418-423, 1978... 

In patients with neuromuscular disorders, assess the respiratory response carefully... 

Death from SNA Intoxication appears to Involve both cardiovascular and respiratory systems. 2 SNA Increases the effects of pentobarbital on both respiration and heart rate. The depressant effects of SNA on the myocardium and on the Purklnje system are antagonized effectively by epinephrine, but not by Metrazol (pentylenetetrazol) and caffeine. Artificial respiration restored cardiac stability and regularity. It was suggested that SNA Interferes with oxygen utilization In animals. The circulatory and respiratory responses to SNA were considered to be mediated through the medulla oblongata. 2... 

Preliminary experimentation on whole carrots utilizing previously reported techniques (17) established the respiratory response of the com-... 

In general, individuals whose ventilatory function is compromised, such as those with emphysema, or individuals with allergic conditions such as asthma, will be at a higher risk of developing adverse respiratory responses when exposed to a strong respiratory irritant such as acrolein. 

Kaplan, H.L., A.Anzueto, W.G.Switzer, and R.K.Hinderer. 1988. Effects of hydrogen chloride on respiratory response and pulmonary function of the baboon. J. Toxicol. Environ. Health 23 (4) 473-493. 

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