Drugs designer, definition

Definitions of some Terms in the Context of Drug Design... 

Before we continue with the description of the drug discovery process, we introduce some terms commonly used in drug design and give their definitions ... 

M. S. Tute, in C. A. Ramsden, vol. ed.. Comprehensive Medicinal Chemisty, Vol. A, Quantitative Drug Design, Pergamon Press, New York, 1990, pp. 1—32. Definition of Molecular Modeling and Uses of CAMM ... 

In order to illustrate an example of process design for the manufacture of enantiopure drug substances on an industrial SMB system, consider manufacturing 10 ton/ year of an enantiopure drug. The racemic drug by definition is a 50 50 mixture of each enantiomer (products A and B). The goal is to process enantiopure drug substances in order to obtain 99 % purity for both the extract and the raffinate. 

Rational design, 148-149, 152 Real-time assays, 83, 88 Receptor(s). See also Drug receptors affinity for, 6, 63 allosteric model of, 143 Clark s work, 3 classical model of, 44-45 concept of, 2-4 conformations, 13-14, 13 Of conservation equation for, 76 constitutive activity of, 49-51 coupling of, 27 definition of, 2 desensitization of, 34 efficacy for, 6... 

In conclusion, until now insufficent data have been available to define general rules to predict for which drugs liposome encapsulation will be therapeutically beneficial when applied to the skin. It is too early to draw definite conclusions about the advantage of the vise of liposomes over alternative dermal delivery systems in the therapy for drugs designed to exert a pharmacological effect either locally or systemically. 

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