Rational drug design definition

Rational design, 148-149, 152 Real-time assays, 83, 88 Receptor(s). See also Drug receptors affinity for, 6, 63 allosteric model of, 143 Clark s work, 3 classical model of, 44-45 concept of, 2-4 conformations, 13-14, 13 Of conservation equation for, 76 constitutive activity of, 49-51 coupling of, 27 definition of, 2 desensitization of, 34 efficacy for, 6... 

By current definition, proteome means simply the internal protein-world of the organism while genome represents its internal DNA world. This definition invokes the all-important issue of three-dimensional structures of proteins, which are in turn the basis of the rational design of drugs. It also invokes many other aspects of protein function, such as protein-protein and protein-drug interactions. Within such broad definition, many companies are now active in areas that can reasonably be described as proteomics. 

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