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Cephalosporins drugs

OCTN2 (SLC22A5) Human TEA, MPP+, L, D-carnitine, acetyl-1-carnitine, betaine, choline, cysteine, lysine, methionine Drugs pyrilamine, quinidine, valproate, verapamil Aldosterone, corticosterone, MPTP, nicotine Drugs cephalosporin antibiotics, cimetidine, clonidine, desipramine, emetine, procainamide, pyrilamine, quinine... [Pg.56]

Dichlorophenyl)-l,2,4-triazine-3,5-diamine (13, Lamotrigine, LTG, BW430C, 430C78)27 and 3-amino-l,2,4-benzotriazine 1,4-dioxide (14, SR4233)440 are used as drugs. Cephalosporins and penicillins with a 1,2,4-triazine moiety have been prepared and found pharmaceutical applications.444... [Pg.583]

Each of the dmgs listed has activity against some gram-negative bacilli. All penicillins should be avoided in patients with a history of allergic reactions to any individual penicillin drug. Cephalosporins should also be avoided in patients who have had anaphylaxis or other severe hypersensitivity reactions following use of a penicillin. There is no cross-reactivity between the penicillins and aztreonam. The answer is (B). [Pg.383]

Triazoles have also been used to improve pharmacokinetic properties of the desired drugs. Cephalosporins with good oral bioavailability were obtained by linking the triazole moiety to the cephalosporin core as in compound 9, shown earlier [24]. [Pg.27]

In spite of the considerable progress in developing methods for total synthesis, this route to cephalosporins cannot compete with fermentation or penicillin rearrangement (see Sections 5.10.4.1 and 2) for the industrial production of cephalosporin antibiotics. While total synthesis does provide access to nuclear analogs not readily obtainable from fermentation products, none of the totally synthetic materials have displayed sufficient advantages to Warrant their development as new drug products (b-81MI51000). [Pg.295]

The total syntheses of penicillin and cephalosporin represent elegant tours de force that demonstrated once again the power of synthetic organic chemistry. These syntheses, however, had little effect on the course of drug development in the respective fields, since they failed to provide access to analogs that could not be prepared by modification of either the side chains or, as in the case of more recent work, modification of 6-APA and 7-ACA themselves. In order to have an impact on drug development, a total synthesis must provide means for preparing... [Pg.418]

Discuss uses, general drug action, adverse reactions, contraindications, precautions, and interactions associated with the cephalosporins. [Pg.75]

SUM MARY DRUG TABLE CEPHALOSPORINS(Cbnf/nued)... [Pg.77]

The cephalosporins also may be used perioperatively, that is, during the preoperative, intraoperative, and postoperative periods, to prevent infection in patients having surgery on a contaminated or potentially contaminated area, such as the gastrointestinal tract or vagina In some instances, a specific drug may be recommended for postoperative prophylactic use only. [Pg.77]

The nurse should use cephalosporins cautiously in patients with renal or hepatic impairment and in patients with bleeding disorders. Safety of cephalosporin administration has not been established in pregnancy or lactation these drugs are assigned to Pregnancy Category B. [Pg.78]

ORAL ADMINISTRATION. The nurse administers cephalosporins around the clock to the patient to provide adequate blood levels. Most cephalosporins may be taken with food to prevent gastric upset. Cefdinir may be taken without regard to food. The absorption of oral cefuroxime and cefpodoxime is increased when given with food. However, if the patient experiences gastrointestinal upset, the nurse can administer the drug with... [Pg.78]

Some cephalosporins are available as powder for a suspension and are reconstituted by a pharmacist or a nurse It is important to keep this form of the drug refrigerated until it is used. [Pg.79]

Rare cases of hemolytic anemia, including fatalities, have been reported with the administration of the cephalosporins. The patient should be monitored for anemia If a patient experiences anemia within 2 to 3 weeks after the start of cephalosporin therapy, drug-induced anemia should be considered. If hemolytic anemia is suspected, the primary health care provider will discontinue the drug therapy. The patient may require blood transfusions to correct tire anemia. Frequent hematological studies may be required. [Pg.79]

The patient is at risk for Stevens-Johnson syndrome when taking the cephalosporins StevensJohnson syndrome is manifested by fever, cough, muscular aches and pains headache, and the appearance of lesions on the skin, mucous membranes and eyes The lesions appear as red wheals or blisters often starting on the face, in the mouth, or on the lips neck, and extremities This syndrome, which also may occur with the administration of other types of drugs can be fatal. The nurse should report any of these symptoms to the primary health care provider immediately. [Pg.80]

A patient who is a recent immigrant to the United Spates is seen in the outpatient clinic for a severe upper respiratory infection. The primary health care provider prescribes a cephalosporin and asks you to give the patient instructions for taking the drug. You note that the patient appears to underhand very little English. Discuss how you would solve this problem. Determine what information you would include in a teaching plan... [Pg.80]

Antibiotics are one ot the most commonly administered types ot drug therapy in the home. Any patient taking antibiotics, especially cephalosporins, is susceptible to superintedion. The nurse makes sure the patient knows the signs and symptoms ot superintedion. [Pg.81]

Meropenem is contraindicated in patients who are allergic to cephalosporins and penicillins and in patients widi renal failure This drug is not recommended... [Pg.102]

The effects of warfarin may increase when administered with acetaminophen, NSAIDs, beta blockers, disulfiram, isoniazid, chloral hydrate, loop diuretics, aminoglycosides, cimetidine, tetracyclines, and cephalosporins. Oral contraceptives, ascorbic acid, barbiturates, diuretics, and vitamin K decrease the effects of warfarin. Because die effects of warfarin are influenced by many drugp, die patient must notify die nurse or die primary healdi care provider when taking a new drug or discontinuing... [Pg.421]


See other pages where Cephalosporins drugs is mentioned: [Pg.189]    [Pg.42]    [Pg.203]    [Pg.174]    [Pg.1229]    [Pg.56]    [Pg.319]    [Pg.203]    [Pg.774]    [Pg.998]    [Pg.174]    [Pg.189]    [Pg.42]    [Pg.203]    [Pg.174]    [Pg.1229]    [Pg.56]    [Pg.319]    [Pg.203]    [Pg.774]    [Pg.998]    [Pg.174]    [Pg.267]    [Pg.203]    [Pg.182]    [Pg.185]    [Pg.192]    [Pg.148]    [Pg.26]    [Pg.70]    [Pg.71]    [Pg.72]    [Pg.75]    [Pg.76]    [Pg.78]    [Pg.78]    [Pg.79]    [Pg.79]    [Pg.79]    [Pg.425]    [Pg.457]    [Pg.129]    [Pg.11]   
See also in sourсe #XX -- [ Pg.291 ]




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