Interactions, drug potential, identifying

It is not hard to predict that with the output of genomics and proteomics, the number of proteins that can be related to specific diseases will increase tremendously in the next few years. Therefore methods that are able to screen combinatorial libraries in the search for interacting drugs are desperately required. Furthermore, efforts to re-examine known drugs for potential interactions with newly identified target proteins will increase, because it lowers costs considerably if a drug that has already passed the regulatory procedures can also be applied to cure a further disease. 

Pravastatin. The clinical relevance of the modest changes in pravastatin levels with different azole antifungals seems likely to be small, and a clinically significant interaction would not be expected. Note that in a review of the FDA spontaneous reports of statin-associated rhabdomyolysis for the period November 1997 to March 2000, azole antifungals were not identified as a potentially interacting drug in any of the reports for pravastatin. ... 

Obtain a complete medical and social history, identifying any potential drug-disease interactions or social factors that may influence treatment choices. 

Identify potential interactions between LT4 and foods and/or drugs. 

Abstract Why do patients refer to medications as the little white pill or the pink capsule Strange or confusing names are problematic especially if you are old and have many medications. Other potential practical medication problems in the elderly including problems to remember, to swallow, practical handling, food- and drug-interactions, short use-before date are listed and described in this chapter. Possible solutions are also presented. For patient safety and for cost-effective care it s very important to identify and solve these problems for the individual patient. A systematic model for this is presented in Chapter 10. 

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